Midroit Maëllie, Chalençon Laura, Renier Nicolas, Milton Adrianna, Thevenet Marc, Sacquet Joëlle, Breton Marine, Forest Jérémy, Noury Norbert, Richard Marion, Raineteau Olivier, Ferdenzi Camille, Fournel Arnaud, Wesson Daniel W, Bensafi Moustafa, Didier Anne, Mandairon Nathalie
CNRS, UMR 5292, INSERM, U1028, Lyon Neuroscience Research Center, Neuroplasticity and Neuropathology of Olfactory Perception Team, Lyon 69000, France; University Lyon, Lyon, 69000, France; University Lyon 1, Villeurbanne 69000, France.
Sorbonne Universités, Paris Brain Institute, ICM, Inserm, CNRS, Paris, France.
Curr Biol. 2021 Apr 26;31(8):1592-1605.e9. doi: 10.1016/j.cub.2021.01.066. Epub 2021 Feb 18.
Pleasant odorants are represented in the posterior olfactory bulb (pOB) in mice. How does this hedonic information generate odor-motivated behaviors? Using optogenetics, we report here that stimulating the representation of pleasant odorants in a sensory structure, the pOB, can be rewarding, self-motivating, and is accompanied by ventral tegmental area activation. To explore the underlying neural circuitry downstream of the olfactory bulb (OB), we use 3D high-resolution imaging and optogenetics and determine that the pOB preferentially projects to the olfactory tubercle, whose increased activity is related to odorant attraction. We further show that attractive odorants act as reinforcers in dopamine-dependent place preference learning. Finally, we extend those findings to humans, who exhibit place preference learning and an increase BOLD signal in the olfactory tubercle in response to attractive odorants. Thus, strong and persistent attraction induced by some odorants is due to a direct gateway from the pOB to the reward system.
在小鼠中，愉悦气味分子在嗅球后部（pOB）中有所体现。这种享乐信息是如何产生受气味驱动的行为的呢？我们在此通过光遗传学技术报告称，刺激感觉结构pOB中愉悦气味分子的表征是有回报的、能自我驱动的，并且伴随着腹侧被盖区的激活。为了探究嗅球（OB）下游的潜在神经回路，我们使用三维高分辨率成像和光遗传学技术，确定pOB优先投射到嗅结节，其活性增加与气味吸引有关。我们进一步表明，有吸引力的气味分子在多巴胺依赖的位置偏好学习中充当强化物。最后，我们将这些发现扩展到人类，人类也表现出位置偏好学习，并且在接触有吸引力的气味分子时，嗅结节中的血氧水平依赖（BOLD）信号会增加。因此，某些气味分子所引发的强烈且持久的吸引力是由于从pOB到奖赏系统的直接通路所致。
