Division of Allergy and Immunology, The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Ann Allergy Asthma Immunol. 2021 May;126(5):469-477. doi: 10.1016/j.anai.2021.02.006. Epub 2021 Feb 16.
Food protein-induced enterocolitis syndrome (FPIES) is a condition with heterogeneous features (ie, age at presentation, severity, food triggers, comorbidities) and is not as rare as initially believed. In the last few years, the first population-based epidemiologic study, few prospective birth cohort evaluating FPIES prevalence, and several larger (>100 patients) studies have been published, making epidemiologic estimation more reliable. In this review, we report on the available data on the epidemiology of FPIES.
PubMed review using the following words: FPIES, epidemiology, and prevalence.
The review focused on the population-based epidemiologic study, few prospective birth cohort evaluating FPIES prevalence, and several larger (>100 patients) studies.
We identified 8 population or cohort studies.
FPIES is not rare in both children and adults and may affect as many as 900,000 people in the United States alone. Most children and adult with FPIES seem to react to 1 to 2 foods; however, they may need further diet restriction owing to high level of comorbidity with immunoglobulin E-mediated food allergies and eosinophilic esophagitis. Globally, cow's milk, rice/oat, and seafood seem to be the most common triggers.
食物蛋白诱导的肠炎综合征（FPIES）是一种具有异质性特征的疾病（即发病年龄、严重程度、食物诱因、合并症），并不像最初认为的那样罕见。在过去几年中，首次进行了基于人群的流行病学研究，少数前瞻性出生队列研究评估了 FPIES 的患病率，以及几项更大规模（>100 例患者）的研究已经发表，使得流行病学估计更加可靠。在这篇综述中，我们报告了 FPIES 流行病学的现有数据。
使用以下词语在 PubMed 上进行综述：FPIES、流行病学和患病率。
综述重点关注基于人群的流行病学研究、少数前瞻性出生队列研究评估 FPIES 的患病率，以及几项更大规模（>100 例患者）的研究。
我们确定了 8 项人群或队列研究。
FPIES 在儿童和成人中都不罕见，仅在美国就可能影响多达 90 万人。大多数患有 FPIES 的儿童和成人似乎对 1 到 2 种食物有反应；然而，由于与免疫球蛋白 E 介导的食物过敏和嗜酸性食管炎的高合并症，他们可能需要进一步限制饮食。在全球范围内，牛奶、大米/燕麦和海鲜似乎是最常见的诱因。
