Hung Lisa, Zientara Brianna, Berin M Cecilia
Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Immunol Rev. 2024 Sep;326(1):35-47. doi: 10.1111/imr.13368. Epub 2024 Jul 25.
Food allergies occur due to a lack of tolerance to the proteins found in foods. While IgE- and non-IgE-mediated food allergies have different clinical manifestations, epidemiology, pathophysiology, and management, they share dysregulated T cell responses. Recent studies have shed light on the contributions of different T cell subsets to the development and persistence of different food allergic diseases. This review discusses the role of T cells in both IgE- and non-IgE-mediated food allergies and considers the potential future investigations in this context.
食物过敏是由于对食物中发现的蛋白质缺乏耐受性而发生的。虽然IgE介导和非IgE介导的食物过敏有不同的临床表现、流行病学、病理生理学和管理方法,但它们都存在T细胞反应失调的情况。最近的研究揭示了不同T细胞亚群在不同食物过敏疾病的发展和持续存在中的作用。这篇综述讨论了T细胞在IgE介导和非IgE介导的食物过敏中的作用,并考虑了在这一背景下未来可能的研究方向。