Kim Jiyoon L, Mestre Beatriz, Shin Sun-Hye, Futerman Anthony H
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Cell Signal. 2021 Jun;82:109958. doi: 10.1016/j.cellsig.2021.109958. Epub 2021 Feb 17.
Sphingolipids are a family of lipids that are critical to cell function and survival. Much of the recent work done on sphingolipids has been performed by a closely-knit family of sphingolipid researchers, which including our colleague, Dr. Lina Obeid, who recently passed away. We now briefly review where the sphingolipid field stands today, focusing in particular on areas of sphingolipid research to which Dr. Obeid made valued contributions. These include the 'many-worlds' view of ceramides and the role of a key enzyme in the sphingolipid biosynthetic pathway, namely the ceramide synthases (CerS). The CerS contain a number of functional domains and also interact with a number of other proteins in lipid metabolic pathways, fulfilling Dr. Obeid's prophecy that ceramides, and the enzymes that generate ceramides, form the critical hub of the sphingolipid metabolic pathway.
鞘脂是一类对细胞功能和存活至关重要的脂质。近期关于鞘脂的许多研究工作都是由一个紧密的鞘脂研究团队完成的，其中包括我们的同事莉娜·奥贝德博士，她最近去世了。我们现在简要回顾一下鞘脂领域目前的状况，特别关注奥贝德博士做出重要贡献的鞘脂研究领域。这些包括神经酰胺的“多世界”观点以及鞘脂生物合成途径中一种关键酶，即神经酰胺合酶（CerS）的作用。CerS包含多个功能域，并且还与脂质代谢途径中的许多其他蛋白质相互作用，这应验了奥贝德博士的预言，即神经酰胺以及产生神经酰胺的酶构成了鞘脂代谢途径的关键枢纽。
