在 TRIUMF 的 ISAC 设施上进行在线同位素分离生产医用放射性核素的潜力，以及对 Er 和 Tb 示例的具体讨论。
Potential for production of medical radionuclides with on-line isotope separation at the ISAC facility at TRIUMF and particular discussion of the examples of Er and Tb.
机构信息
Life Sciences Division, TRIUMF, Vancouver, British Columbia V6T 2A3, Canada; Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
Accelerator Division, TRIUMF, Vancouver, British Columbia V6T 2A3, Canada.
出版信息
Nucl Med Biol. 2021 Mar-Apr;94-95:81-91. doi: 10.1016/j.nucmedbio.2021.01.003. Epub 2021 Jan 28.
Production of medical radionuclides with ISOL facilities is a unique production method that may provide access to preclinical quantities of some rare and potent radionuclides for nuclear medicine. Particularly attention over the past years was focused on several promising candidates for Targeted Radionuclides Therapy (TRT). With this review, we provide some perspectives of using the TRIUMF ISOL facility (ISAC) to produce medical radionuclides for TRT application and highlight our current effort to collect of Er and Tb for Auger Therapy and SPECT imaging, respectively.
利用 ISOL 设施生产医用放射性核素是一种独特的生产方法，可为核医学提供一些罕见强效放射性核素的临床前用量。近年来，人们特别关注几种有前途的用于靶向放射性核素治疗（TRT）的候选放射性核素。在本文中，我们提供了使用 TRIUMF ISOL 设施（ISAC）生产用于 TRT 应用的医用放射性核素的一些观点，并重点介绍了我们目前分别为 Auger 治疗和单光子发射计算机断层扫描（SPECT）成像收集 Er 和 Tb 的工作。
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