用于靶向放射性核素治疗的迈特纳-俄歇电子发射器：汞-197m/g 和锑-119。
Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119.
机构信息
Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada.
Department of Medical Physics and Radiology, University of Wisconsin, Madison, WI, United States.
出版信息
Curr Radiopharm. 2021;14(4):394-419. doi: 10.2174/1874471014999210111201630.
Abstract
Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony- 119 (Sb) and mercury-197 (Hg). Both radionuclides have great potential to become efficient tools for TRT. We also highlight our current progress on the production of both radionuclides at TRIUMF and the University of Wisconsin.
摘要
基于 Auger 发射放射性核素的靶向放射性核素疗法 (TRT) 有可能在细胞水平上提供极其选择性的治疗有效载荷。然而，为了充分发挥这种潜力，需要将合适的放射性核素与适当的输送系统结合使用。在这篇综述中，我们总结了两种有前途的靶向 Auger 疗法候选物——锑-119 (Sb) 和汞-197 (Hg)——的最新生产、纯化、螯合和应用情况。这两种放射性核素都有很大的潜力成为 TRT 的有效工具。我们还强调了我们在 TRIUMF 和威斯康星大学生产这两种放射性核素的当前进展。
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