维生素 D 结合蛋白与 COVID-19 的遗传学研究
A genetic insight into vitamin D binding protein and COVID-19.
机构信息
Department of Clinical Pharmacy, Faculty of Pharmacy Ain Shams University, Cairo, Egypt.
出版信息
Med Hypotheses. 2021 Apr;149:110531. doi: 10.1016/j.mehy.2021.110531. Epub 2021 Feb 9.
Abstract
It's since December 2019 that Corona virus disease (COVID-19) has emerged to be the global issue of concern. A "pandemic"; this is what WHO has declared about the COVID-19 outbreak on March 3rd, 2020. Vitamin D and its deficiency have recently been claimed to be one of the potential factors affecting COVID-19 risks and outcomes [1]. As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I'd believe that vitamin D binding protein (DBP) is maybe also involved. A closer look on DBP and its action on regulating the circulatory vitamin D levels, its polymorphisms and their impact on COVID-19 prevalence and mortality, will be briefly discussed.
摘要
自 2019 年 12 月以来，冠状病毒病（COVID-19）已成为全球关注的问题。2020 年 3 月 3 日，世界卫生组织宣布 COVID-19 爆发为“大流行”。最近有人声称，维生素 D 及其缺乏是影响 COVID-19 风险和结果的潜在因素之一[1]。正如 Selberstein 等人最近讨论的维生素 D 缺乏的影响，以及维生素 D 补充剂在 COVID-19 患者中的作用[2]，我认为维生素 D 结合蛋白（DBP）也可能参与其中。本文将简要讨论 DBP 及其调节循环维生素 D 水平的作用、多态性及其对 COVID-19 患病率和死亡率的影响。
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