Altern Ther Health Med. 2021 Jun;27(S1):178-184.
According to the criteria of the International Classification of Sleep Disorders (ICSD-3), it is estimated that the prevalence of insomnia in the general population varies between 6.6% and 12%. Insomnia is a sleep disturbance related to a reduction in the quality or quantity of satisfactory sleep. Among the available treatments, there are both pharmacological and non-pharmacological approaches. One recent possible non-pharmacological approach that has been suggested is based on the use of probiotics and the gut-brain axis. There has been increasing scientific focus on this area because of the suggested importance of enteric microbiota in relation to many aspects of health. It has been proposed that probiotics can be used to interact with the intestinal environment to benefit individuals suffering from a variety of conditions. In relation to sleep, some studies have indicated that gamma-amino butyric acid (GABA) produced by the intestinal microbiota may influence the central nervous system (CNS) through the vagus nerve and have an influence on sleep. In this sense, Lactobacillus is one of the major GABA producing bacteria in the gut microbiota.
Our hypothesis is that supplementation with Lactobacillus as a probiotic might improve sleep pattern and quality, acting as an ally in the treatment of insomnia.
In the present study, a search was conducted in Pubmed and Google Scholar databases, looking for articles with themes related to probiotics, intestinal microbiota and sleep.
No clinical trials were found that evaluated the effect of probiotics for sleep disorders in humans.Conclusions • Research and clinical use of probiotics have been growing due to their health benefits in several areas. In addition, the use of probiotics for sleep and emotional disorders, such as insomnia, stress, anxiety and depression, is gaining space. This way, future research can help developing complementary treatments for people with insomnia and other sleep disorders.
根据国际睡眠障碍分类（ICSD-3）的标准，估计普通人群中失眠的患病率在 6.6%至 12%之间。失眠是一种与睡眠质量或数量下降有关的睡眠障碍。在现有的治疗方法中，既有药物治疗，也有非药物治疗。最近提出的一种可能的非药物治疗方法是基于使用益生菌和肠脑轴。由于肠道微生物群在许多健康方面的重要性，科学界对这一领域的关注度越来越高。有人提出，益生菌可以用来与肠道环境相互作用，使患有各种疾病的个体受益。就睡眠而言，一些研究表明，肠道微生物群产生的γ-氨基丁酸（GABA）可能通过迷走神经影响中枢神经系统（CNS），并对睡眠产生影响。在这方面，乳杆菌是肠道微生物群中主要的 GABA 产生菌之一。
我们的假设是，补充益生菌乳杆菌可能会改善睡眠模式和质量，成为治疗失眠的盟友。
本研究在 Pubmed 和 Google Scholar 数据库中进行了检索，寻找与益生菌、肠道微生物群和睡眠相关的主题文章。
未发现评估益生菌对人类睡眠障碍影响的临床试验。结论：由于益生菌在许多领域对健康有益，因此其研究和临床应用一直在增长。此外，益生菌在睡眠和情绪障碍（如失眠、压力、焦虑和抑郁）方面的应用也在不断增加。这样，未来的研究可以帮助开发针对失眠和其他睡眠障碍患者的补充治疗方法。
