Kang Yongbo, Kang Xing, Cai Yue
Department of microbiology and immunology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, China.
Department of microbiology and immunology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, China.
Clin Res Hepatol Gastroenterol. 2022 Jan;46(1):101834. doi: 10.1016/j.clinre.2021.101834. Epub 2021 Nov 18.
Insomnia is a type of sleep disorder which has negative impacts on the quality of life, mood, cognitive function and health of humans. The etiology of insomnia may be related to many factors such as genetics, biochemistry, neuroendocrine, immune, and psychosocial factors. However, the detailed pathological aspects of insomnia remain unclear. Recent investigation of the microbiome-gut-brain axis enhances our understanding of the role of the gut microbiota in brain-related diseases. Gut microbiome has been shown to be associated with insomnia. However, the available data in this field remain limited and the relevant scientific work has only recently begun. This review aims to summarize the recent literature as an aid to better understanding how the alteration of gut microbiota composition contributes to insomnia while evaluating and prospecting the therapeutic effect of modulating gut microbiota in the treatment of insomnia based on previous publications.
失眠是一种睡眠障碍，对人类的生活质量、情绪、认知功能和健康产生负面影响。失眠的病因可能与许多因素有关，如遗传、生物化学、神经内分泌、免疫和心理社会因素。然而，失眠详细的病理方面仍不清楚。最近对微生物群-肠-脑轴的研究加深了我们对肠道微生物群在脑相关疾病中作用的理解。肠道微生物群已被证明与失眠有关。然而，该领域的现有数据仍然有限，相关的科学工作直到最近才开始。这篇综述旨在总结近期文献，以帮助更好地理解肠道微生物群组成的改变如何导致失眠，同时根据以往的出版物评估和展望调节肠道微生物群在治疗失眠中的疗效。
