Wang Haoran, Li Xiaoqing, Wang Sheng, Liu Jun, Xie Ning
Department of Orthopaedics, Tongji Hospital of Tongji University, Tongji University School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
Department of Geriatrics, Sir Run Run Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Drug Des Devel Ther. 2025 Jul 7;19:5801-5819. doi: 10.2147/DDDT.S523151. eCollection 2025.
In recent years, the research on the occurrence and development of interleukin in intervertebral disc degeneration has been more and more extensive. The purpose of this study is to predict the future research direction or prospect by analyzing the relevant literature in this field.
Interleukin family cytokines are becoming more and more important in the research field of intervertebral disc degeneration, but all previous studies only focus on one aspect and are not comprehensive. We revealed the most influential countries and institutions in the field of interleukin, cytokine and intervertebral disc therapy. Systematic analysis of interleukin family cytokines and intervertebral disc degeneration and summary of related mechanisms will help to further promote the progress of related clinical treatment.
The related articles published in 1 January 2015-1 December 2024 were all from network science (WOS), and charts were made and analyzed by using social science statistics software package and GraphPad Prism 8 software. Using VOS viewer software and CiteSpace software, the research trend of keywords is analyzed visually.
China has made the most significant contribution in this field. In addition, the research papers on IL-1 cytokines and intervertebral disc degeneration are the most, and Huazhong University of Science and Technology has published the most papers. Spine is the magazine that publishes the largest number of related documents. Preclinical medicine, especially immunology, plays a key role in this field. In hot spots, the focus of research can be divided into two parts (intervertebral disc degeneration and nucleus pulposus cells; The expression of interleukin and cytokine).
This marks the first bibliometric analysis in this field and provides a comprehensive literature overview. Our findings clarify the future research direction and various cooperative relationships. Targeted therapy for interleukin and cytokine may be an important development trend in the future.
近年来，白细胞介素在椎间盘退变发生发展中的研究越来越广泛。本研究旨在通过分析该领域的相关文献来预测未来的研究方向或前景。
白细胞介素家族细胞因子在椎间盘退变研究领域越来越重要，但以往所有研究都只侧重于某一方面，不够全面。我们揭示了白细胞介素、细胞因子及椎间盘治疗领域最具影响力的国家和机构。系统分析白细胞介素家族细胞因子与椎间盘退变并总结相关机制，将有助于进一步推动相关临床治疗的进展。
检索2015年1月1日至2024年12月1日发表的相关文章，均来自网络科学（WOS），并使用社会科学统计软件包和GraphPad Prism 8软件制作图表并进行分析。使用VOS viewer软件和CiteSpace软件对关键词的研究趋势进行可视化分析。
中国在该领域贡献最为显著。此外，关于白细胞介素-1细胞因子与椎间盘退变的研究论文最多，华中科技大学发表的论文数量最多。《脊柱》是发表相关文献数量最多的杂志。基础医学，尤其是免疫学，在该领域发挥着关键作用。在热点方面，研究重点可分为两部分（椎间盘退变与髓核细胞；白细胞介素和细胞因子的表达）。
这标志着该领域首次进行文献计量分析，并提供了全面的文献综述。我们的研究结果明确了未来的研究方向和各种合作关系。针对白细胞介素和细胞因子的靶向治疗可能是未来的一个重要发展趋势。
