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通过人工智能驱动的计算建模推动个性化医学取得成功。

Driving success in personalized medicine through AI-enabled computational modeling.

机构信息

VeriSIM Life Inc., 1 Sansome St. Suite 3500, San Francisco, CA 94104, USA.

VeriSIM Life Inc., 1 Sansome St. Suite 3500, San Francisco, CA 94104, USA.

出版信息

Drug Discov Today. 2021 Jun;26(6):1459-1465. doi: 10.1016/j.drudis.2021.02.007. Epub 2021 Feb 17.

Abstract

The development of successful drugs is expensive and time-consuming because of high clinical attrition rates. This is caused partially by the rupture seen in the translatability of the drug from the bench to the clinic in the context of personalized medicine. Artificial intelligence (AI)-driven platforms integrated with mechanistic modeling have become instrumental in accelerating the drug development process by leveraging data ubiquitously across the various phases. AI can counter the deficiencies and ambiguities that arise during the classical drug development process while reducing human intervention and bridging the translational gap in discovering the connections between drugs and diseases.

摘要

成功药物的研发既昂贵又耗时,因为临床淘汰率很高。这部分是由于在个性化医学背景下,药物从实验室到临床的可转化性出现了破裂。人工智能 (AI) 驱动的平台与机械建模相结合,通过在各个阶段广泛利用数据,成为加速药物开发过程的有力工具。人工智能可以克服经典药物开发过程中出现的缺陷和模糊性,同时减少人为干预并缩小发现药物与疾病之间联系的转化差距。

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