Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.
Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
Drug Discov Today. 2021 Jun;26(6):1473-1481. doi: 10.1016/j.drudis.2021.02.009. Epub 2021 Feb 18.
The novel respiratory virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), emerged during late 2019 and spread rapidly across the world. It is now recognised that the nervous system can be affected in COVID-19, with several studies reporting long-term cognitive problems in patients. The metabolic pathway of tryptophan degradation, known as the kynurenine pathway (KP), is significantly activated in patients with COVID-19. KP metabolites have roles in regulating both inflammatory/immune responses and neurological functions. In this review, we speculate on the effects of KP activation in patients with COVID-19, and how modulation of this pathway might impact inflammation and reduce neurological symptoms.
新型呼吸病毒严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）可引起 2019 年冠状病毒病（COVID-19），于 2019 年末出现并迅速在全球范围内传播。目前已经认识到，COVID-19 会影响神经系统，多项研究报告称患者存在长期认知问题。色氨酸降解的代谢途径，即犬尿氨酸途径（KP），在 COVID-19 患者中明显被激活。KP 代谢产物在调节炎症/免疫反应和神经功能方面发挥作用。在这篇综述中，我们推测 COVID-19 患者中 KP 激活的影响，以及该途径的调节如何影响炎症并减轻神经症状。
