真菌多糖促进保护性免疫。
Fungal Polysaccharides Promote Protective Immunity.
机构信息
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Univ Angers, Université de Nantes, CHU d'Angers, Inserm, CRCINA, SFR ICAT, F-49000 Angers, France.
出版信息
Trends Microbiol. 2021 May;29(5):379-381. doi: 10.1016/j.tim.2021.02.004. Epub 2021 Feb 17.
Fungal pathogens represent a rising threat against immunocompromised patients. By using Aspergillus fumigatus, Briard et al. showed that the cell wall galactosaminogalactan (GAG) triggers macrophage inflammasome activation, promoting protective immunity. This provides new insights into the role of GAG in host-pathogen interactions and also perspectives for developing GAG-based anti-inflammatory therapeutics.
真菌病原体对免疫功能低下的患者构成了日益严重的威胁。Briard 等人利用烟曲霉表明，细胞壁半乳氨基半乳糖聚糖（GAG）触发巨噬细胞炎性体激活，促进保护性免疫。这为 GAG 在宿主-病原体相互作用中的作用提供了新的见解，并为开发基于 GAG 的抗炎治疗提供了新视角。
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