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脂质/聚合物纳米复合物在核酸传递中的应用：作为癌症疫苗。

Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines.

机构信息

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.

出版信息

Drug Discov Today. 2021 Aug;26(8):1891-1903. doi: 10.1016/j.drudis.2021.02.013. Epub 2021 Feb 18.

DOI:10.1016/j.drudis.2021.02.013
PMID:33610757
Abstract

Cancer vaccines consist of nucleic acid derivatives such as plasmid DNA, small interfering RNA and mRNA, and can be customized according to the patient's needs. Nanomedicines have proven to be exceptionally good as miniaturized drug carriers, and thus they offer great advantages for delivering cancer vaccines. This review provides an overview of the literature on cancer vaccines, from their inception to current developments in the field.

摘要

癌症疫苗由核酸衍生物组成，如质粒 DNA、小干扰 RNA 和 mRNA，并可根据患者的需求定制。纳米药物已被证明是非常好的微型药物载体，因此它们在递送癌症疫苗方面具有很大的优势。本文综述了癌症疫苗的文献，从其起源到该领域的当前发展。

相似文献

[1]
Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines.

Drug Discov Today. 2021-8

[2]
Lipid- and Polymer-Based Nanocarrier Platforms for Cancer Vaccine Delivery.

ACS Appl Bio Mater. 2024-8-19

[3]
Emerging advances in delivery systems for mRNA cancer vaccines.

J Control Release. 2024-6

[4]
Polymers for nucleic acid transfer-an overview.

Adv Genet. 2014

[5]
Nucleic acid-loaded lipid-polymer nanohybrids as novel nanotherapeutics in anticancer therapy.

Expert Opin Drug Deliv. 2020-6

[6]
Self-aggregating 1.8kDa polyethylenimines with dissolution switch at endosomal acidic pH are delivery carriers for plasmid DNA, mRNA, siRNA and exon-skipping oligonucleotides.

J Control Release. 2016-12-9

[7]
Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering RNA delivery.

Angew Chem Int Ed Engl. 2011-7-25

[8]
Self-assembling complexes between binary mixtures of lipids with different linkers and nucleic acids promote universal mRNA, DNA and siRNA delivery.

J Control Release. 2017-2-1

[9]
Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination.

J Gene Med. 2019-5-10

[10]
Lipid-Based Vectors for Therapeutic mRNA-Based Anti-Cancer Vaccines.

Curr Pharm Des. 2019

引用本文的文献

[1]
Breaking barriers: Smart vaccine platforms for cancer immunomodulation.

Cancer Commun (Lond). 2025-5

[2]
Chitosan non-particulate vaccine delivery systems.

J Pharm Pharm Sci. 2024-7-24

[3]
From structural design to delivery: mRNA therapeutics for cancer immunotherapy.

Exploration (Beijing). 2023-11-17

[4]
Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer.

Molecules. 2024-2-29

[5]
Lipid Nanoparticle-Based Delivery System-A Competing Place for mRNA Vaccines.

ACS Omega. 2024-1-30

[6]
An Overview of the Stability and Delivery Challenges of Commercial Nucleic Acid Therapeutics.

Pharmaceutics. 2023-4-6

[7]
Combining 3D Printing and Microfluidic Techniques: A Powerful Synergy for Nanomedicine.

Pharmaceuticals (Basel). 2023-1-1

[8]
Evolution of complexity in non-viral oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles.

RNA Biol. 2022-1

[9]
The Role of Cryoprotective Agents in Liposome Stabilization and Preservation.

Int J Mol Sci. 2022-10-18

[10]
Identification of personalized neoantigen-based vaccines and immune subtype characteristic analysis of glioblastoma based on abnormal alternative splicing.

Am J Cancer Res. 2022-8-15

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