• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

壳聚糖非微粒疫苗递送系统

Chitosan non-particulate vaccine delivery systems.

作者信息

Masimov Rasim, Wasan Ellen K

机构信息

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.

出版信息

J Pharm Pharm Sci. 2024 Jul 24;27:12921. doi: 10.3389/jpps.2024.12921. eCollection 2024.

DOI:10.3389/jpps.2024.12921
PMID:39114808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11303186/
Abstract

Chitosan is an extensively used polymer for drug delivery applications in particulate and non-particulate carriers. Chitosan-based particulate, nano-, and microparticle, carriers have been the most extensively studied for the delivery of therapeutics and vaccines. However, chitosan has also been used in vaccine applications for its adjuvant properties in various hydrogels or as a carrier coating material. The focus of this review will be on the usage of chitosan as a vaccine adjuvant based on its intrinsic immunogenicity; the various forms of chitosan-based non-particulate delivery systems such as thermosensitive hydrogels, microneedles, and conjugates; and the advantages of its role as a coating material for vaccine carriers.

摘要

壳聚糖是一种广泛应用于药物递送的聚合物，可用于颗粒和非颗粒载体。基于壳聚糖的颗粒、纳米和微粒载体在治疗药物和疫苗递送方面得到了最为广泛的研究。然而，壳聚糖还因其在各种水凝胶中的佐剂特性或作为载体包衣材料而被用于疫苗应用。本综述的重点将是基于壳聚糖固有的免疫原性，探讨其作为疫苗佐剂的用途；基于壳聚糖的各种非颗粒递送系统，如热敏水凝胶、微针和结合物；以及其作为疫苗载体包衣材料的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/a39b52d64f63/jpps-27-12921-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/419aa157fd4c/jpps-27-12921-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/497037a1f8f3/jpps-27-12921-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/3f78e8a5dace/jpps-27-12921-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/d5e682197329/jpps-27-12921-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/8c19c0106da8/jpps-27-12921-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/e4f25f2ad5f2/jpps-27-12921-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/9767498dc0a9/jpps-27-12921-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/a39b52d64f63/jpps-27-12921-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/419aa157fd4c/jpps-27-12921-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/497037a1f8f3/jpps-27-12921-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/3f78e8a5dace/jpps-27-12921-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/d5e682197329/jpps-27-12921-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/8c19c0106da8/jpps-27-12921-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/e4f25f2ad5f2/jpps-27-12921-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/9767498dc0a9/jpps-27-12921-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f012/11303186/a39b52d64f63/jpps-27-12921-g008.jpg

相似文献

1
Chitosan non-particulate vaccine delivery systems.壳聚糖非微粒疫苗递送系统
J Pharm Pharm Sci. 2024 Jul 24;27:12921. doi: 10.3389/jpps.2024.12921. eCollection 2024.
2
Comparison of chitosan nanoparticles and chitosan hydrogels for vaccine delivery.用于疫苗递送的壳聚糖纳米颗粒与壳聚糖水凝胶的比较。
J Pharm Pharmacol. 2008 Dec;60(12):1591-600. doi: 10.1211/jpp/60.12.0004.
3
Chemical Modification of Chitosan for Efficient Vaccine Delivery.壳聚糖的化学修饰用于高效疫苗传递。
Molecules. 2018 Jan 25;23(2):229. doi: 10.3390/molecules23020229.
4
Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems.载有脂质体和立方脂载体的壳聚糖水凝胶作为微粒持续释放疫苗给药系统。
J Liposome Res. 2012 Sep;22(3):193-204. doi: 10.3109/08982104.2011.637502. Epub 2011 Dec 22.
5
Advances and Potential Applications of Chitosan Nanoparticles as a Delivery Carrier for the Mucosal Immunity of Vaccine.壳聚糖纳米颗粒作为疫苗黏膜免疫递送载体的研究进展及潜在应用
Curr Drug Deliv. 2017;14(1):27-35. doi: 10.2174/1567201813666160804121123.
6
Chitosan-based particulate systems for the delivery of mucosal vaccines against infectious diseases.壳聚糖基微粒系统用于递送针对传染病的粘膜疫苗。
Int J Biol Macromol. 2018 Apr 15;110:54-64. doi: 10.1016/j.ijbiomac.2017.10.101. Epub 2017 Oct 18.
7
Novel application of trimethyl chitosan as an adjuvant in vaccine delivery.三甲基壳聚糖作为佐剂在疫苗传递中的新应用。
Int J Nanomedicine. 2018 Nov 23;13:7959-7970. doi: 10.2147/IJN.S165876. eCollection 2018.
8
Chitosan-based hydrogels for controlled, localized drug delivery.壳聚糖基水凝胶用于控制和局部药物传递。
Adv Drug Deliv Rev. 2010 Jan 31;62(1):83-99. doi: 10.1016/j.addr.2009.07.019. Epub 2009 Sep 30.
9
Controlled Liposome Delivery from Chitosan-Based Thermosensitive Hydrogel for Regenerative Medicine.壳聚糖基温敏水凝胶控制脂质体给药用于再生医学。
Int J Mol Sci. 2022 Jan 14;23(2):894. doi: 10.3390/ijms23020894.
10
In vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine delivery.含硅纳米粒子的温敏壳聚糖水凝胶的体内外研究及其在疫苗传递中的应用。
Eur J Pharm Sci. 2010 Oct 9;41(2):360-8. doi: 10.1016/j.ejps.2010.07.004. Epub 2010 Jul 13.

本文引用的文献

1
Polymeric Delivery Systems as a Potential Vaccine against Visceral Leishmaniasis: Formulation Development and Immunogenicity.作为治疗内脏利什曼病潜在疫苗的聚合物递送系统：制剂开发与免疫原性
Vaccines (Basel). 2023 Jul 31;11(8):1309. doi: 10.3390/vaccines11081309.
2
Application of microneedles combined with dendritic cell-targeted nanovaccine delivery system in percutaneous immunotherapy for triple-negative breast cancer.微针联合树突状细胞靶向纳米疫苗递送系统在三阴性乳腺癌经皮免疫治疗中的应用
Nanotechnology. 2023 Sep 5;34(47). doi: 10.1088/1361-6528/ace97b.
3
Oral delivery of a Streptococcus agalactiae vaccine to Nile tilapia (Oreochromis niloticus) using a novel cationic-based nanoemulsion containing bile salts.
利用一种新型的含胆汁盐的阳离子纳米乳剂经口向尼罗罗非鱼（Oreochromis niloticus）传递无乳链球菌疫苗。
Fish Shellfish Immunol. 2023 Aug;139:108913. doi: 10.1016/j.fsi.2023.108913. Epub 2023 Jun 29.
4
A synthetic Tn-BSA conjugate vaccine bearing chitotriose as built-in adjuvant.一种含有壳三糖作为内置佐剂的合成 Tn-BSA 缀合物疫苗。
Carbohydr Res. 2023 Aug;530:108875. doi: 10.1016/j.carres.2023.108875. Epub 2023 Jun 16.
5
A novel vaccine formulation candidate based on lipooligosaccharides and pertussis toxin against .基于脂寡糖和百日咳毒素的新型疫苗制剂候选物针对 。
Front Immunol. 2023 Apr 27;14:1124695. doi: 10.3389/fimmu.2023.1124695. eCollection 2023.
6
Design and evaluation of chitosan-amino acid thermosensitive hydrogel.壳聚糖-氨基酸热敏水凝胶的设计与评价
Mar Life Sci Technol. 2021 Sep 16;4(1):74-87. doi: 10.1007/s42995-021-00116-9. eCollection 2022 Feb.
7
Immunological evaluation of a recombinant vaccine delivered with an analogous hyaluronic acid chitosan nanoparticle-hydrogel against Toxoplasma gondii in mice.免疫评估一种用类似透明质酸壳聚糖纳米颗粒-水凝胶递呈的重组疫苗对小鼠弓形虫的作用。
Microb Pathog. 2023 Jun;179:106092. doi: 10.1016/j.micpath.2023.106092. Epub 2023 Mar 30.
8
Commercial influenza vaccines vary in HA-complex structure and in induction of cross-reactive HA antibodies.商业流感疫苗在 HA 复合物结构和诱导交叉反应性 HA 抗体方面存在差异。
Nat Commun. 2023 Mar 30;14(1):1763. doi: 10.1038/s41467-023-37162-z.
9
Optimization of storage conditions for lipid nanoparticle-formulated self-replicating RNA vaccines.优化脂质纳米颗粒配方自复制 RNA 疫苗的储存条件。
J Control Release. 2023 Jan;353:241-253. doi: 10.1016/j.jconrel.2022.11.022. Epub 2022 Nov 30.
10
Nucleic Acid Vaccines against SARS-CoV-2.针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的核酸疫苗
Vaccines (Basel). 2022 Oct 31;10(11):1849. doi: 10.3390/vaccines10111849.