全基因组重测序确定藏羊品种的遗传多样性和种群结构。

Genetic diversity and population structure of Tibetan sheep breeds determined by whole genome resequencing.

机构信息

Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, 810016, China.

出版信息

Trop Anim Health Prod. 2021 Feb 20;53(1):174. doi: 10.1007/s11250-021-02605-6.

DOI:10.1007/s11250-021-02605-6

PMID:33611716

Abstract

Tibetan sheep is one of primitive Chinese sheep breeds, which achieved the divergence about 2500 years ago in Qinghai plateau region. According to different geographic conditions, especially altitudes, Tibetan sheep evolved into different breeds. In this study, we performed whole genome resequencing of 5 representative Tibetan sheep breeds. Comparative genomic analysis showed that they can be divided into different clades with a close genetic relationship. However, some genes with common selective regions were enriched for hypoxic adaptability in different breeds living at higher altitude, including GHR, BMP15, and CPLANE1. Furthermore, breed-specific selective regions about physical characteristics, especially wool growth, were found in genes such as BSND, USP24, NCAPG, and LCORL. This study could contribute to our understanding about trait formation and offer a reference for breeding of Tibetan sheep.

摘要

藏羊是中国原始绵羊品种之一，约 2500 年前在青藏高原地区发生分化。根据不同的地理条件，特别是海拔高度，藏羊进化为不同的品种。在本研究中，我们对 5 个具有代表性的藏羊品种进行了全基因组重测序。比较基因组分析表明，它们可以分为不同的分支，具有密切的遗传关系。然而，一些具有共同选择区域的基因在不同品种中对高海拔的低氧适应性进行了富集，包括 GHR、BMP15 和 CPLANE1。此外，在与物理特征相关的基因中，如 BSND、USP24、NCAPG 和 LCORL，发现了与品种特异性相关的选择区域，特别是羊毛生长。本研究有助于我们了解性状形成，并为藏羊的选育提供参考。