Consultant Gastroenterologist, 29448Bombay Hospital and Medical Research Centre, Mumbai, India.
Resident Doctor, Department of Gastroenterology, 29448Bombay Hospital and Medical Research Centre, Mumbai, India.
Trop Doct. 2021 Apr;51(2):228-231. doi: 10.1177/0049475521991353. Epub 2021 Feb 21.
In Scrunb Typhus, hepatotoxicity is an important, yet understudied, manifestation. We reviewed studies on scrub typhus, published in the last five years (2014-2019), which evaluated its clinico-epidemiological factors in India, and concentrated on its hepatic involvement. Nine studies were found, and no Indian study exclusively evaluated hepatic dysfunction. Thus, comments from a few international studies were also included. We conclude that liver dysfunction in the form of elevated serum transaminase levels is a common manifestation of scrub typhus, which may herald progress to fulminant hepatic failure.
在恙虫病中，肝毒性是一种重要但研究不足的表现。我们回顾了过去五年（2014-2019 年）发表的关于恙虫病的研究，这些研究评估了印度恙虫病的临床流行病学因素，并集中研究了其肝脏受累情况。共发现了 9 项研究，但没有一项印度研究专门评估肝功能障碍。因此，也包括了一些国际研究的评论。我们的结论是，血清转氨酶水平升高形式的肝功能障碍是恙虫病的常见表现，可能预示着暴发性肝衰竭的进展。
