Hissa R, George J C, Stevens E D, Saarela S
Acta Physiol Scand. 1980 Oct;110(2):175-80. doi: 10.1111/j.1748-1716.1980.tb06648.x.
Intravenous injections of different doses of tyramine induced hypothermia in the pigeon in the cold and a moderate hyperthermia in the warm environment. The hypothermia was correlated with a dose-dependent decline in shivering. Hyperthermia was attributed to the chrono- and inotropic effects of tyramine. The indirect stimulatory effects of noradrenaline (NA) at the tissue level were studied. Pretreatment with alpha-methyl-para-tyrosine (alpha-MpT) and blocking alpha-adrenoceptors with phentolamine, diminished the hypothermia induced by tyramine in the cold. The results obtained indicate that the release of endogenous NA stimulated by tyramine might result either in hypothermia or hyperthermia, thus resembling similar effects obtained with exogenous NA in birds.
静脉注射不同剂量的酪胺会使处于寒冷环境中的鸽子体温过低，而在温暖环境中则会导致适度的体温过高。体温过低与寒战的剂量依赖性下降相关。体温过高归因于酪胺的变时性和变力性作用。研究了去甲肾上腺素（NA）在组织水平的间接刺激作用。用α-甲基对酪氨酸（α-MpT）预处理并用酚妥拉明阻断α-肾上腺素能受体，可减轻寒冷环境中酪胺诱导的体温过低。所得结果表明，酪胺刺激内源性NA的释放可能导致体温过低或过高，因此类似于在鸟类中外源性NA所产生的类似效应。
