Warepam Marina, Mishra Awdhesh Kumar, Sharma Gurumayum Suraj, Kumari Kritika, Krishna Snigdha, Khan Mohd Sajjad Ahmad, Rahman Hamidur, Singh Laishram Rajendrakumar
Department of Biotechnology, Manipur University, Manipur, India.
Department of Biotechnology, Yeungnam University, Gyeongsan-si, South Korea.
Front Cell Neurosci. 2021 Feb 5;15:617308. doi: 10.3389/fncel.2021.617308. eCollection 2021.
Deposition of toxic protein inclusions is a common hallmark of many neurodegenerative disorders including Alzheimer's disease, Parkinson disease etc. N-acetylaspartate (NAA) is an important brain metabolite whose levels got altered under various neurodegenerative conditions. Indeed, NAA has been a widely accepted biological marker for various neurological disorders. We have also reported that NAA is a protein stabilizer. In the present communication, we investigated the role of NAA in modulating the aggregation propensity on two model proteins (carbonic anhydrase and catalase). We discovered that NAA suppresses protein aggregation and could solubilize preformed aggregates.
毒性蛋白包涵体的沉积是包括阿尔茨海默病、帕金森病等在内的许多神经退行性疾病的共同特征。N-乙酰天门冬氨酸（NAA）是一种重要的脑代谢物，其水平在各种神经退行性疾病状态下会发生改变。事实上，NAA一直是各种神经疾病广泛认可的生物标志物。我们还报道过NAA是一种蛋白质稳定剂。在本通讯中，我们研究了NAA在调节两种模型蛋白（碳酸酐酶和过氧化氢酶）聚集倾向方面的作用。我们发现NAA可抑制蛋白质聚集，并能溶解预先形成的聚集体。
