• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

轻度创伤性脑损伤的质子磁共振波谱分析

Proton MR spectroscopy in mild traumatic brain injury.

作者信息

Kubas Bożena, Lebkowski Wojciech, Lebkowska Urszula, Kułak Wojciech, Tarasow Eugeniusz, Walecki Jerzy

机构信息

Radiology Department, Medical University of Bialystok, Bialystok, Poland.

出版信息

Pol J Radiol. 2010 Oct;75(4):7-10.

PMID:22802797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3389892/
Abstract

BACKGROUND

To assess the role of 1H MRS in the detection of changes in cerebral metabolite levels in pyramidal tracts after mild traumatic brain injury (MTBI) and to compare metabolite alterations to the clinical status (Glasgow Coma Scale).

MATERIAL/METHODS: Study group consisted of 25 patients after mild traumatic brain injury, with a score of 11 to 15 in GCS. The MR studies were performed with a 1.5 T scanner. The results of spectra approximation (presented as metabolite ratios: NAA/Cr, NAA/Cho, Cho/Cr, lac/Cr, lip/Cr, Glx/Cr) were subjected to statistical analysis. MR spectra were recorded from a normal-appearing brain region: internal capsules and cerebral peduncles. Spectra from traumatic patients were compared with a control group including 34 healthy volunteers recorded with the same techniques.

RESULTS

The statistical analysis revealed significant differences between the data obtained from various brain regions of the same patients after an MTBI and between the study and the control group. Proton MR spectroscopy detects changes in cerebral metabolite levels in apparently normal regions. In pyramidal tracts (internal capsules, cerebral peduncles), we noticed a significant reduction of NAA /Cho, lip/Cr, lac/Cr and Glx/Cr.

CONCLUSIONS

In patients with mild brain injury, we can detect some metabolite abnormalities in normal-appearing brain structures. Proton MRS is a very useful tool for evaluation of major changes in metabolite levels in pyramidal tracts after mild traumatic brain injury.

摘要

背景

评估氢质子磁共振波谱（1H MRS）在检测轻度创伤性脑损伤（MTBI）后锥体束中脑代谢物水平变化中的作用，并将代谢物改变与临床状态（格拉斯哥昏迷量表）进行比较。

材料/方法：研究组由25例轻度创伤性脑损伤患者组成，格拉斯哥昏迷量表评分为11至15分。使用1.5T扫描仪进行磁共振研究。对波谱近似结果（以代谢物比率表示：NAA/Cr、NAA/Cho、Cho/Cr、lac/Cr、lip/Cr、Glx/Cr）进行统计分析。从外观正常的脑区：内囊和大脑脚记录磁共振波谱。将创伤患者的波谱与包括34名健康志愿者在内的对照组进行比较，对照组采用相同技术记录。

结果

统计分析显示，MTBI后同一患者不同脑区获得的数据之间以及研究组与对照组之间存在显著差异。质子磁共振波谱可检测出外观正常区域脑代谢物水平的变化。在锥体束（内囊、大脑脚）中，我们注意到NAA/Cho、lip/Cr、lac/Cr和Glx/Cr显著降低。

结论

在轻度脑损伤患者中，我们可以在外观正常的脑结构中检测到一些代谢物异常。质子MRS是评估轻度创伤性脑损伤后锥体束中代谢物水平主要变化的非常有用的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f0/3389892/3fd6deefd868/poljradiol-75-4-7-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f0/3389892/86548dd8fddd/poljradiol-75-4-7-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f0/3389892/6a5d9a22fa10/poljradiol-75-4-7-i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f0/3389892/1650bd60ed26/poljradiol-75-4-7-i003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f0/3389892/3fd6deefd868/poljradiol-75-4-7-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f0/3389892/86548dd8fddd/poljradiol-75-4-7-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f0/3389892/6a5d9a22fa10/poljradiol-75-4-7-i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f0/3389892/1650bd60ed26/poljradiol-75-4-7-i003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f0/3389892/3fd6deefd868/poljradiol-75-4-7-g004.jpg

相似文献

1
Proton MR spectroscopy in mild traumatic brain injury.轻度创伤性脑损伤的质子磁共振波谱分析
Pol J Radiol. 2010 Oct;75(4):7-10.
2
Metabolite Profile in Pyramidal Tracts after Ischemic Brain Stroke Assessed by 1H MRS. A Multicenter Study.通过1H磁共振波谱评估缺血性脑卒中后锥体束中的代谢物谱：一项多中心研究
Neuroradiol J. 2007 Jan 31;19(6):699-704. doi: 10.1177/197140090601900602. Epub 2007 Jan 14.
3
Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations.围产期脑缺氧缺血性损伤新生儿的质子磁共振波谱分析：代谢物峰面积比、弛豫时间和绝对浓度
AJNR Am J Neuroradiol. 2006 Aug;27(7):1546-54.
4
Multivoxel proton magnetic resonance spectroscopy in heat stroke.中暑的多体素质子磁共振波谱分析
Clin Radiol. 2015 Jan;70(1):37-41. doi: 10.1016/j.crad.2014.09.004. Epub 2014 Nov 4.
5
Neurometabolites Alteration in the Acute Phase of Mild Traumatic Brain Injury (mTBI): An In Vivo Proton Magnetic Resonance Spectroscopy (1H-MRS) Study.轻度创伤性脑损伤（mTBI）急性期神经代谢物的改变：一项体内质子磁共振波谱（1H-MRS）研究。
Acad Radiol. 2018 Sep;25(9):1167-1177. doi: 10.1016/j.acra.2018.01.005. Epub 2018 Feb 12.
6
Volumetric proton spectroscopic imaging of mild traumatic brain injury.轻度创伤性脑损伤的容积质子磁共振波谱成像
AJNR Am J Neuroradiol. 2004 May;25(5):730-7.
7
Assessment of mitochondrial impairment in traumatic brain injury using high-resolution proton magnetic resonance spectroscopy.使用高分辨率质子磁共振波谱评估创伤性脑损伤中的线粒体损伤。
J Neurosurg. 2008 Jan;108(1):42-52. doi: 10.3171/JNS/2008/108/01/0042.
8
Characterizing 'mild' in traumatic brain injury with proton MR spectroscopy in the thalamus: Initial findings.利用质子磁共振波谱对丘脑创伤性脑损伤中的“轻度”进行特征描述：初步研究结果。
Brain Inj. 2007 Oct;21(11):1147-54. doi: 10.1080/02699050701630383.
9
Proton Magnetic Resonance Spectroscopy (¹H-MRS) Study of Early Traumatic Brain Injury in Rabbits.兔早期创伤性脑损伤的质子磁共振波谱（¹H-MRS）研究
Med Sci Monit. 2017 May 19;23:2365-2372. doi: 10.12659/msm.904788.
10
Temporal window of metabolic brain vulnerability to concussion: a pilot 1H-magnetic resonance spectroscopic study in concussed athletes--part III.代谢性脑震荡易损性的时间窗：对脑震荡运动员的一项1H磁共振波谱学初步研究——第三部分
Neurosurgery. 2008 Jun;62(6):1286-95; discussion 1295-6. doi: 10.1227/01.neu.0000333300.34189.74.

引用本文的文献

1
Neurometabolite alterations in traumatic brain injury and associations with chronic pain.创伤性脑损伤中的神经代谢物改变及其与慢性疼痛的关联
Front Neurosci. 2023 Feb 23;17:1125128. doi: 10.3389/fnins.2023.1125128. eCollection 2023.
2
Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta-Analysis.创伤性脑损伤和亚震荡性打击的磁共振波谱分析：系统评价和荟萃分析。
J Neurotrauma. 2022 Nov;39(21-22):1455-1476. doi: 10.1089/neu.2022.0125. Epub 2022 Aug 16.
3
Review: Emerging Eye-Based Diagnostic Technologies for Traumatic Brain Injury.

本文引用的文献

1
Metabolite Profile in Pyramidal Tracts after Ischemic Brain Stroke Assessed by 1H MRS. A Multicenter Study.通过1H磁共振波谱评估缺血性脑卒中后锥体束中的代谢物谱：一项多中心研究
Neuroradiol J. 2007 Jan 31;19(6):699-704. doi: 10.1177/197140090601900602. Epub 2007 Jan 14.
2
An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study.痉挛型双瘫患儿基底节区代谢物浓度的年龄和性别依赖性：质子磁共振波谱研究
J Child Neurol. 2009 Jan;24(1):73-9. doi: 10.1177/0883073808321058. Epub 2008 Oct 20.
3
Prognostic role of proton magnetic resonance spectroscopy in acute traumatic brain injury.
综述：创伤性脑损伤的新兴眼部诊断技术。
IEEE Rev Biomed Eng. 2023;16:530-559. doi: 10.1109/RBME.2022.3161352. Epub 2023 Jan 5.
4
Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities.创伤性脑损伤及相关合并症中含胆碱磷脂的动力学。
Int J Mol Sci. 2021 Oct 20;22(21):11313. doi: 10.3390/ijms222111313.
5
Associations Between Neurochemistry and Gait Performance Following Concussion in Collegiate Athletes.大学生运动员脑化学与脑震荡后步态表现的相关性研究。
J Head Trauma Rehabil. 2020 Sep/Oct;35(5):342-353. doi: 10.1097/HTR.0000000000000616.
6
Elevated cerebrospinal fluid concentrations of N-acetylaspartate correlate with poor outcome in a pilot study of severe brain trauma.在一项重度脑外伤的初步研究中，脑脊液中N-乙酰天门冬氨酸浓度升高与不良预后相关。
Brain Inj. 2019;33(10):1364-1371. doi: 10.1080/02699052.2019.1641743. Epub 2019 Jul 15.
7
Sport-Related Concussion: Evaluation, Treatment, and Future Directions.运动相关脑震荡：评估、治疗及未来方向
Med Sci (Basel). 2019 Mar 15;7(3):44. doi: 10.3390/medsci7030044.
8
Multimodal Imaging of Neurometabolic Pathology due to Traumatic Brain Injury.创伤性脑损伤所致神经代谢病理学的多模态成像
Trends Neurosci. 2017 Jan;40(1):39-59. doi: 10.1016/j.tins.2016.10.007. Epub 2016 Dec 9.
质子磁共振波谱在急性创伤性脑损伤中的预后作用
J Head Trauma Rehabil. 2006 Jul-Aug;21(4):334-49. doi: 10.1097/00001199-200607000-00005.
4
Early morphologic and spectroscopic magnetic resonance in severe traumatic brain injuries can detect "invisible brain stem damage" and predict "vegetative states".严重创伤性脑损伤的早期形态学和光谱磁共振成像能够检测出“隐匿性脑干损伤”并预测“植物状态”。
J Neurotrauma. 2006 May;23(5):674-85. doi: 10.1089/neu.2006.23.674.
5
Proton MR spectroscopic imaging depicts diffuse axonal injury in children with traumatic brain injury.质子磁共振波谱成像可显示创伤性脑损伤患儿的弥漫性轴索损伤。
AJNR Am J Neuroradiol. 2005 May;26(5):1276-85.
6
Late proton MR spectroscopy in children after traumatic brain injury: correlation with cognitive outcomes.创伤性脑损伤后儿童的晚期质子磁共振波谱分析：与认知结果的相关性
AJNR Am J Neuroradiol. 2005 Mar;26(3):482-8.
7
Proton magnetic resonance spectroscopy in children with spastic diplegia.痉挛性双侧瘫患儿的质子磁共振波谱分析
Neurosci Lett. 2004 Jun 3;363(1):62-4. doi: 10.1016/j.neulet.2004.03.043.
8
Volumetric proton spectroscopic imaging of mild traumatic brain injury.轻度创伤性脑损伤的容积质子磁共振波谱成像
AJNR Am J Neuroradiol. 2004 May;25(5):730-7.
9
Hydrogen-1 MR spectroscopy of the peritumoral zone in patients with cerebral glioma: assessment of the value of the method.脑胶质瘤患者瘤周区域的氢质子磁共振波谱分析：该方法的价值评估
Acad Radiol. 2003 Feb;10(2):145-53. doi: 10.1016/s1076-6332(03)80038-7.
10
How useful is magnetic resonance imaging in predicting severity and outcome in traumatic brain injury?磁共振成像在预测创伤性脑损伤的严重程度和预后方面有多大作用？
Curr Opin Neurol. 2001 Dec;14(6):753-7. doi: 10.1097/00019052-200112000-00012.