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兰伯特-伊顿肌无力综合征自主神经功能异常

Abnormalities of autonomic function in the Lambert Eaton myasthenic syndrome.

作者信息

Heath J P, Ewing D J, Cull R E

机构信息

Department of Neurology, Royal Infirmary, Edinburgh, UK.

出版信息

J Neurol Neurosurg Psychiatry. 1988 Mar;51(3):436-9. doi: 10.1136/jnnp.51.3.436.

DOI:10.1136/jnnp.51.3.436
PMID:3361337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1032876/
Abstract

Two cases of Lambert Eaton syndrome unassociated with an underlying malignancy are described. Both had mild autonomic symptoms but markedly abnormal autonomic function tests. These results are suggestive of a widespread defect in cholinergic transmission in addition to that at the skeletal neuromuscular junction.

摘要

本文描述了两例与潜在恶性肿瘤无关的兰伯特-伊顿综合征病例。两者均有轻度自主神经症状，但自主神经功能测试明显异常。这些结果提示，除了骨骼肌神经肌肉接头处存在缺陷外，胆碱能传递也存在广泛缺陷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/1032876/0f323f1d5d1c/jnnpsyc00538-0113-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/1032876/0f323f1d5d1c/jnnpsyc00538-0113-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/1032876/0f323f1d5d1c/jnnpsyc00538-0113-a.jpg

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本文引用的文献

1
Electromyography and electric stimulation of nerves in diseases of motor unit; observations on myasthenic syndrome associated with malignant tumors.运动单位疾病中的肌电图和神经电刺激；对与恶性肿瘤相关的肌无力综合征的观察。
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Treatment of Lambert-Eaton syndrome: 3,4-diaminopyridine and pyridostigmine.兰伯特-伊顿综合征的治疗：3,4-二氨基吡啶和溴吡斯的明。
Neurology. 1984 Oct;34(10):1324-30. doi: 10.1212/wnl.34.10.1324.
3
Plasma exchange and immunosuppressive drug treatment in the Lambert-Eaton myasthenic syndrome.
将兰伯特-伊顿综合征被动转移至小鼠会诱导神经肌肉传递的二氢吡啶敏感性。
J Physiol. 2002 Sep 1;543(Pt 2):567-76. doi: 10.1113/jphysiol.2002.021048.
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Autonomic dysfunction in Lambert-Eaton myasthenic syndrome.兰伯特-伊顿肌无力综合征中的自主神经功能障碍。
Clin Auton Res. 2001 Jun;11(3):145-54. doi: 10.1007/BF02329922.
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Lambert-Eaton myasthenic syndrome.兰伯特-伊顿肌无力综合征
Postgrad Med J. 1999 Sep;75(887):516-20. doi: 10.1136/pgmj.75.887.516.
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Postganglionic cholinergic dysautonomia with incomplete recovery: a clinical, neurophysiological and immunological case study.
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Neuromuscular transmission in nude mice bearing oat cell tumors from Lambert-Eaton myasthenic syndrome.患有燕麦细胞肿瘤的裸鼠中与兰伯特-伊顿肌无力综合征相关的神经肌肉传递
Muscle Nerve. 1982;5(9S):S39-45.
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Autoimmunity in the Lambert-Eaton myasthenic syndrome.
Muscle Nerve. 1982;5(9S):S21-5.
6
The carcinomatous neuromyopathy of oat cell lung cancer.燕麦细胞肺癌的癌性神经肌病
Ann Neurol. 1980 Jan;7(1):65-72. doi: 10.1002/ana.410070112.
7
Autoimmune aetiology for myasthenic (Eaton-Lambert) syndrome.肌无力（伊顿-兰伯特）综合征的自身免疫病因
Lancet. 1981 Aug 1;2(8240):224-6. doi: 10.1016/s0140-6736(81)90474-8.
8
Defects of neuromuscular transmission in syndromes other than myasthenia gravis.重症肌无力以外综合征中的神经肌肉传递缺陷。
Ann N Y Acad Sci. 1966 Jan 26;135(1):367-84. doi: 10.1111/j.1749-6632.1966.tb45484.x.
9
Detailed analysis of neuromuscular transmission in a patient with the myasthenic syndrome sometimes associated with bronchogenic carcinoma.对一名有时与支气管源性癌相关的肌无力综合征患者的神经肌肉传递进行详细分析。
Mayo Clin Proc. 1968 Oct;43(10):689-713.
10
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Thorax. 1986 May;41(5):372-5. doi: 10.1136/thx.41.5.372.