Nicola Marta, Onorati Monica, Lancia Mauro, Varca Virginia, Di Nuovo Franca
Pathology, ASST Rhodense, Garbagnate Milanese, ITA.
Urology, ASST Rhodense, Garbagnate Milanese, ITA.
Cureus. 2021 Jan 18;13(1):e12771. doi: 10.7759/cureus.12771.
Histiocytic sarcoma (HS) is a rare malignant lymphohematopoietic neoplasm; it has been cited in the recent World Health Organization (WHO) classification as a malignant proliferation of cells exhibiting morphological and immunophenotypic features of mature histiocytes. To our knowledge, the present case is the first to be described in the bladder of a patient without a history of lymphoma. Only one case has been reported so far regarding a secondary bladder presentation in the setting of a previous diffuse large B-cell lymphoma. We discuss the case of a 68-year-old male who presented with hematuria and dysuria. CT scan revealed a 4-cm intravesical mass that histological examination defined as HS. Our objective was to describe the clinical, histological, immunophenotypical, molecular characteristics and discuss the differential diagnoses of this first case of primary bladder HS. Our research was based on a review of selected articles obtained via the PubMed database. This extremely rare experience provided us with the opportunity to depict an interesting case, highlight its uniqueness, and build up new pathological evidence.
组织细胞肉瘤（HS）是一种罕见的恶性淋巴造血肿瘤；在最近的世界卫生组织（WHO）分类中，它被定义为具有成熟组织细胞形态和免疫表型特征的细胞恶性增殖。据我们所知，本病例是首例在无淋巴瘤病史的患者膀胱中发现的病例。迄今为止，仅报道过1例先前患有弥漫性大B细胞淋巴瘤继发膀胱受累的病例。我们讨论了1例68岁男性患者，该患者出现血尿和排尿困难。CT扫描显示膀胱内有一个4厘米的肿块，组织学检查确诊为HS。我们的目的是描述这例原发性膀胱HS首例病例的临床、组织学、免疫表型、分子特征，并讨论其鉴别诊断。我们的研究基于对通过PubMed数据库获取的精选文章的综述。这一极为罕见的经历让我们有机会描述一个有趣的病例，突出其独特性，并积累新的病理学证据。
