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一例表现为鼻内肿瘤的鼻面部真菌感染

A Rhinofacial Fungal Infection Presenting as an Intranasal Tumour.

作者信息

Deak Levente, Mudalagiriyappa Savitha, Ballin Annelyse, Saxton David, Chakrabarti Arunaloke

机构信息

Department of Ear, Nose & Throat, Suliaman Al Habib Hospital, Dubai, UAE.

Department of Microbiology, Al Zahra Hospital, Dubai, UAE.

出版信息

Sultan Qaboos Univ Med J. 2018 Nov;18(4):e549-e552. doi: 10.18295/squmj.2018.18.04.022. Epub 2019 Mar 28.

Abstract

Conidiobolomycosis is a rare fungal infection that affects adults in tropical regions. We report a 42-year-old male patient who was referred to the Sulaiman Al Habib Hospital, Dubai, United Arab Emirates (UAE), in 2013 with excessive nasal bleeding and a suspected nasal tumour. He reported having briefly visited central India nine months previously. Computed tomography and magnetic resonance imaging showed a highly vascularised mass in the nasal cavity. However, after surgical excision, initial treatment with amphotericin B deoxycholate was unsuccessful and the disease progressed, leading to external and internal nasal deformation and necessitating further excision and facial reconstruction. Histopathological analysis of the second biopsy revealed Splendore-Hoeppli changes consistent with a fungal infection. Microbiological findings subsequently confirmed . Subsequently, the patient was successfully treated with a combination of itraconazole and fluconazole. To the best of the authors' knowledge, this is the first report of a case of rhinofacial conidiobolomycosis from the UAE.

摘要

耳霉病是一种罕见的真菌感染,影响热带地区的成年人。我们报告一例42岁男性患者,2013年因鼻出血过多且疑似鼻腔肿瘤被转诊至阿拉伯联合酋长国迪拜的苏莱曼·哈比卜医院。他报告称9个月前曾短暂访问印度中部。计算机断层扫描和磁共振成像显示鼻腔内有一个血管高度丰富的肿块。然而,手术切除后,使用去氧胆酸盐两性霉素B进行的初始治疗未成功,疾病进展,导致鼻外部和内部变形,需要进一步切除和面部重建。第二次活检的组织病理学分析显示有与真菌感染一致的Splendore-Hoeppli变化。微生物学检查结果随后得以证实。随后,该患者接受伊曲康唑和氟康唑联合治疗成功。据作者所知,这是阿拉伯联合酋长国首例鼻面部耳霉病病例报告。

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A Rhinofacial Fungal Infection Presenting as an Intranasal Tumour.一例表现为鼻内肿瘤的鼻面部真菌感染
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Clin Dermatol. 2012 Jul-Aug;30(4):409-12. doi: 10.1016/j.clindermatol.2011.09.012.
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Disseminated human conidiobolomycosis due to Conidiobolus lamprauges. 人播散性亮丝虫草病由亮丝虫草引起。
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