Amalakanti Sridhar, Arepalli Kesava Venkata Raman, Jillella Jyothi Priya
Institute of Bioinformatics, Discoverer Building, 7th Floor, International Tech Park, Whitefield, 560066 Bengaluru, India.
Department of General Medicine, Great Eastern Medical School and Hospital, Ragolu, India.
Virusdisease. 2021 Mar;32(1):146-149. doi: 10.1007/s13337-021-00663-w. Epub 2021 Feb 15.
Neurological features of COVID-19 have been reported in addition to the respiratory manifestations, but cognitive dysfunction has been scarcely described. And cognitive assessment has not been studied in asymptomatic subjects. We compared the cognitive assessment scores between asymptomatic SARS-CoV-2 infected subjects with that of controls to detect mild cognitive impairment by the Montreal Cognitive Assessment test. Asymptomatic COVID-19 subjects secured lower scores in certain domains of the MoCA in comparison with the controls. The domains were visuoperception (2.4 ± 0.7 vs2.8 ± 0.7, = 0.032), naming (3.6 ± 0.5 vs3.9 ± 0.2, = 0.016) and fluency (0.9 ± 0.6 vs1.6 ± 0.7, = < 0.001). Also, older aged COVID-19 positive subjects scored lower in the MoCA when compared to the younger people. Our study shows that even otherwise asymptomatic COVID-19 subjects have cognitive deficits in certain subdomains and suggests the need for a detailed psychometric assessment especially in the elderly population.
The online version of this article (10.1007/s13337-021-00663-w).
除呼吸道表现外，已有关于新冠病毒病（COVID-19）神经学特征的报道，但认知功能障碍鲜有描述。且尚未对无症状感染者进行认知评估研究。我们通过蒙特利尔认知评估测试比较无症状严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染者与对照组的认知评估得分，以检测轻度认知障碍。与对照组相比，无症状COVID-19感染者在蒙特利尔认知评估量表（MoCA）的某些领域得分较低。这些领域包括视觉感知（2.4±0.7对2.8±0.7，P = 0.032）、命名（3.6±0.5对3.9±0.2，P = 0.016）和流畅性（0.9±0.6对1.6±0.7，P ＜0.001）。此外，年龄较大的COVID-19阳性受试者在MoCA中的得分低于年轻人。我们的研究表明，即使是无症状的COVID-19感染者在某些子领域也存在认知缺陷，并提示尤其在老年人群中需要进行详细的心理测量评估。
本文的在线版本（10.1007/s13337-021-00663-w）。
