Clabaut M, Duclos R, Acritopoulou-Fourcroy S
Laboratory of Foeto-Maternal Physiopathology, Faculty of Sciences, University of Rouen, Mont-Saint-Aignan, France.
J Reprod Fertil. 1988 Mar;82(2):545-51. doi: 10.1530/jrf.0.0820545.
Comparison of uterine activities recorded during the control period to those obtained during the two recording periods after ovariectomy (0-30 min and 30-60 min) showed an increase of the amplitude of uterine contractions (P less than 0.005) and a decrease of the interval between two successive uterine contractions (P less than 0.005) and the delay of electrical activities (P less than 0.005). Progesterone treatment (50 mg/kg i.m.) of ovariectomized rats prevented the abrupt fall in plasma progesterone concentrations, measured by RIA, which in turn inhibited the increase of uterine mechanical and electrical activities. A close relation between the increase of myometrial activity and the decrease of progesterone concentrations after ovariectomy is suggested. The activation of the myometrium would be principally induced by the fall of progesterone or by the variation of the oestrogen/progesterone ratio; these changes in sexual steroid hormones would augment the uterine sensitivity to physiological stimuli or modify the activity of other factors involved in the regulation of the myometrium.
将对照组期间记录的子宫活动与卵巢切除术后两个记录期（0 - 30分钟和30 - 60分钟）获得的子宫活动进行比较，结果显示子宫收缩幅度增加（P < 0.005），两次连续子宫收缩之间的间隔缩短（P < 0.005），电活动延迟（P < 0.005）。对卵巢切除大鼠进行孕酮治疗（50 mg/kg，肌肉注射）可防止通过放射免疫分析测定的血浆孕酮浓度急剧下降，这反过来又抑制了子宫机械和电活动的增加。提示卵巢切除术后子宫肌层活动增加与孕酮浓度降低之间存在密切关系。子宫肌层的激活主要由孕酮下降或雌激素/孕酮比值变化引起；这些性类固醇激素的变化会增强子宫对生理刺激的敏感性或改变参与子宫肌层调节的其他因素的活性。
