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关节镜下Bankart修复术后使用非甾体抗炎药治疗的患者阿片类药物使用量减少:一项随机对照研究。

Opioid Use Is Reduced in Patients Treated with NSAIDs After Arthroscopic Bankart Repair: A Randomized Controlled Study.

作者信息

Thompson Kamali A, Klein David, Alaia Michael J, Strauss Eric J, Jazrawi Laith M, Campbell Kirk A

机构信息

Division of Sports Medicine, Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, NYU Langone Health, New York, New York.

出版信息

Arthrosc Sports Med Rehabil. 2020 Dec 27;3(1):e15-e22. doi: 10.1016/j.asmr.2020.08.003. eCollection 2021 Feb.

Abstract

PURPOSE

To evaluate the efficacy of oral nonsteroidal anti-inflammatory drugs (NSAIDs) as the primary postoperative pain medication compared with standard oral opioids after arthroscopic shoulder capsulolabral (Bankart) repair for recurrent anterior shoulder instability.

METHODS

This was a single-center, prospective, randomized controlled study. Patients aged 18 to 65 years indicated for arthroscopic shoulder capsulolabral repair for recurrent anterior shoulder instability were included. Postoperatively, patients were prescribed 1 of 2 analgesic regimens: (1) 30 ibuprofen (600 mg every 6 to 8 hours as needed) and 10 tablets of oxycodone/acetaminophen (5/325 mg every 6 hours as needed for breakthrough pain) or (2) 30 tablets oxycodone/acetaminophen (5/325 mg every 6 hours as needed). Subjects completed questionnaires at 24, 48, and 96 hours and 1 week after surgery, which included questions about analgesic medication usage, visual analog scale (VAS) pain score, incidence of adverse events, and patient satisfaction.

RESULTS

Between December 2017 and May 2019, 80 patients (mean age 31.3 ± 10.4 years) were enrolled. Overall there were no significant differences in VAS pain score or patient satisfaction between the 2 groups. Patients in the opioid-only group had a significantly higher mean opioid consumption on postoperative days (PODs) 2 to 4 (5.5 versus 2.9,  = .05) and after 1 week (11.7 versus 7.9 tablets,  = .05) compared with patients in the NSAID group. Of patients in the NSAID group, 17.5% experienced adverse effects, compared with 35% in the opioid-only group.

CONCLUSIONS

Use of oral NSAIDs with limited breakthrough opioids results in significantly less opioid use after arthroscopic Bankart repair in the first postoperative week compared with opioids only. Both groups used limited amounts of opioids to control postoperative pain. There were no differences in pain levels at any time point postoperatively or satisfaction between patient groups.

LEVEL OF EVIDENCE

II, nonblinded randomized control trial.

摘要

目的

评估在复发性肩关节前脱位的关节镜下肩关节囊盂唇(Bankart)修复术后,口服非甾体抗炎药(NSAIDs)作为主要术后止痛药与标准口服阿片类药物相比的疗效。

方法

这是一项单中心、前瞻性、随机对照研究。纳入年龄在18至65岁之间、因复发性肩关节前脱位而行关节镜下肩关节囊盂唇修复术的患者。术后,患者被给予两种镇痛方案中的一种:(1)30片布洛芬(按需每6至8小时服用600毫克)和10片羟考酮/对乙酰氨基酚(按需每6小时服用5/325毫克用于爆发痛)或(2)30片羟考酮/对乙酰氨基酚(按需每6小时服用5/325毫克)。受试者在术后24、48和96小时以及1周时完成问卷,问卷包括关于止痛药使用情况、视觉模拟量表(VAS)疼痛评分、不良事件发生率和患者满意度的问题。

结果

2017年12月至2019年5月期间,共纳入80例患者(平均年龄31.3±10.4岁)。总体而言,两组之间的VAS疼痛评分或患者满意度无显著差异。与非甾体抗炎药组患者相比,仅使用阿片类药物组的患者在术后第2至4天(5.5片对2.9片,P = 0.05)和1周后(11.7片对7.9片,P = 0.05)的平均阿片类药物消耗量显著更高。非甾体抗炎药组中17.5%的患者出现不良反应,而仅使用阿片类药物组为35%。

结论

与仅使用阿片类药物相比,在术后第一周,关节镜下Bankart修复术后使用口服非甾体抗炎药并辅以有限的爆发性阿片类药物可显著减少阿片类药物的使用。两组均使用有限量的阿片类药物来控制术后疼痛。术后任何时间点的疼痛水平或患者组之间的满意度均无差异。

证据级别

II,非盲法随机对照试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6233/7879172/a7210801413f/gr1.jpg

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