Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, M5G 1G6, Canada.
Department of Chemistry, University of Toronto, 80 George Street, Toronto, Ontario, M5S 3H6, Canada.
Macromol Biosci. 2021 Apr;21(4):e2000365. doi: 10.1002/mabi.202000365. Epub 2021 Feb 22.
Biomaterial scaffolds have been gaining momentum in the past several decades for their potential applications in the area of tissue engineering. They function as three-dimensional porous constructs to temporarily support the attachment of cells, subsequently influencing cell behaviors such as proliferation and differentiation to repair or regenerate defective tissues. In addition, scaffolds can also serve as delivery vehicles to achieve sustained release of encapsulated growth factors or therapeutic agents to further modulate the regeneration process. Given the limitations of current bone grafts used clinically in bone repair, alternatives such as biomaterial scaffolds have emerged as potential bone graft substitutes. This review summarizes how physicochemical properties of biomaterial scaffolds can influence cell behavior and its downstream effect, particularly in its application to bone regeneration.
生物材料支架在过去几十年中因其在组织工程领域的潜在应用而备受关注。它们作为三维多孔结构，可以暂时支撑细胞的附着，随后影响细胞的行为，如增殖和分化，以修复或再生有缺陷的组织。此外，支架还可以作为载体，实现封装生长因子或治疗剂的持续释放，以进一步调节再生过程。鉴于目前临床上用于骨修复的骨移植物的局限性，生物材料支架等替代品已经成为潜在的骨移植物替代品。本文综述了生物材料支架的物理化学性质如何影响细胞行为及其下游效应，特别是在骨再生中的应用。
