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使用 Gafchromic™ EBT-XD 胶片对 SBRT/SRS 治疗计划进行绝对剂量验证的方案。

A protocol for absolute dose verification of SBRT/SRS treatment plans using Gafchromic™ EBT-XD films.

机构信息

Physics Department, University of Coimbra, Coimbra, Portugal; Medical Physics Department, IPOCFG, E.P.E., Coimbra, Portugal.

Medical Physics Department, IPOCFG, E.P.E., Coimbra, Portugal.

出版信息

Phys Med. 2021 Feb;82:150-157. doi: 10.1016/j.ejmp.2021.01.082. Epub 2021 Feb 19.

Abstract

PURPOSE

To provide a practical protocol for absolute dose verification of stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) treatment plans, based on our clinical experience. It aims to be a concise summary of the main aspects to be considered when establishing an accurate film dosimetry system.

METHODS

Procedures for film calibration and conversion to dose are described for a dosimetry system composed of Gafchromic™ EBT-XD films and a flatbed document scanner. Factors that affect the film-scanner response are also reviewed and accounted for. The accuracy of the proposed methodology was assessed by taking a set of strips irradiated to known doses and its applicability is illustrated for ten SBRT/SRS treatment plans. The film response was converted to dose using red and triple channel dosimetry. The agreement between the planned and measured dose distributions was evaluated using global gamma analysis with criteria of 3%/2mm 10% threshold (TH), 2%/2mm 10% TH, and 2%/2mm 20% TH.

RESULTS

The differences between the expected and determined doses from the strips analysis were 0.9 ± 0.6% for the red channel and 1.1 ± 0.7% for the triple channel method. Regarding the SBRT/SRS plans verification, the mean gamma passing rates were 99.5 ± 1.0% vs 99.6 ± 1.0% (3%/2mm 10% TH), 96.9 ± 3.5% vs 99.1 ± 1.3% (2%/2mm 10% TH) and 98.4 ± 1.8% vs 98.8 ± 1.5% (2%/2mm 20% TH) for red and triple channel dosimetry, respectively.

CONCLUSIONS

The proposed protocol allows for accurate absolute dose verification of SBRT/SRS treatment plans, applying both single and triple channel methods. It may work as a guide for users that intend to implement a film dosimetry system.

摘要

目的

根据我们的临床经验,提供一种用于立体定向体部放疗(SBRT)和立体定向放射外科(SRS)治疗计划的绝对剂量验证的实用方案。其旨在简明扼要地总结建立准确胶片剂量学系统时需要考虑的主要方面。

方法

描述了由 Gafchromic™ EBT-XD 胶片和平板文档扫描仪组成的剂量学系统的胶片校准和剂量转换过程。还回顾了影响胶片-扫描仪响应的因素,并进行了相应的考虑。通过一组照射到已知剂量的条带评估了所提出方法的准确性,并说明了其在十个 SBRT/SRS 治疗计划中的适用性。使用红通道和三通道剂量学将胶片响应转换为剂量。使用 3%/2mm 10%阈值(TH)、2%/2mm 10%TH 和 2%/2mm 20%TH 的全局伽马分析评估计划剂量分布与测量剂量分布的一致性。

结果

从条带分析得出的预期剂量与确定剂量之间的差异分别为红通道 0.9±0.6%和三通道 1.1±0.7%。对于 SBRT/SRS 计划验证,红通道和三通道剂量学的平均伽马通过率分别为 99.5±1.0%与 99.6±1.0%(3%/2mm 10%TH)、96.9±3.5%与 99.1±1.3%(2%/2mm 10%TH)和 98.4±1.8%与 98.8±1.5%(2%/2mm 20%TH)。

结论

所提出的方案允许使用单通道和三通道方法对 SBRT/SRS 治疗计划进行准确的绝对剂量验证。它可以作为希望实施胶片剂量学系统的用户的指南。

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