School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Curr Opin Cell Biol. 2021 Apr;69:127-135. doi: 10.1016/j.ceb.2021.01.005. Epub 2021 Feb 20.
Current advances are raising our awareness of the diverse roles that protein condensation plays in the biology of cells. Particularly, findings in organisms as diverse as yeast and Drosophila suggest that cells may utilize protein condensation to establish long-lasting changes in cellular activities and thereby encode a memory of past signaling events. Proteins that oligomerize to confer such cellular memory have been termed 'mnemons'. In the forming of super-assemblies, mnemons change their function and modulate the influence that the affected protein originally had on cellular processes. Because mnemon assemblies are self-templating, they allow cells to retain the memory of past decisions over larger timescales. Here, we review the mechanisms behind the formation of cellular memory with an emphasis on mnemon-mediated memorization of past signaling events.
目前的进展提高了我们对蛋白质凝聚在细胞生物学中发挥的多种作用的认识。特别是，在酵母和果蝇等不同生物中的发现表明，细胞可能利用蛋白质凝聚来建立细胞活动的持久变化，从而编码对过去信号事件的记忆。将蛋白质寡聚化以赋予这种细胞记忆的蛋白质已被称为“记忆子”。在形成超组装体的过程中，记忆子改变其功能并调节受影响蛋白质最初对细胞过程的影响。由于记忆组装体是自模板化的，因此它们允许细胞在更长的时间尺度上保留过去决策的记忆。在这里，我们重点讨论了记忆子介导的过去信号事件记忆的形成机制，以回顾细胞记忆的形成机制。
