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头皮无痛性软组织肿块的不常见病因:原发性颅内神经内分泌肿瘤的罕见表现。

Unusual cause of a painless soft tissue mass of the scalp: a rare presentation of primary intracranial neuroendocrine neoplasm.

机构信息

Neurosurgery, Southampton University Hospitals NHS Trust, Southampton, UK.

School of Medicine, Cardiff University, Cardiff, UK

出版信息

BMJ Case Rep. 2021 Feb 22;14(2):e236856. doi: 10.1136/bcr-2020-236856.

Abstract

Incidental soft tissue lumps in the scalp are a common presenting complaint in clinical practice. However, they may signify more sinister underlying pathologies. Our report examines a 63-year-old man presenting with impaired co-ordination in his left hand following a 3-month history of a painless left retroauricular scalp lump. MRI revealed a large left occipital soft tissue mass eroding through the underlying skull with infiltration into the underlying cerebellum and temporal lobe. Open biopsy confirmed a diagnosis of high-grade intracranial neuroendocrine tumour (NET). At approximately 5 months following successful tumour resection and adjuvant chemotherapy, he developed tumour recurrence and was subsequently palliated, and died at 1 year post diagnosis. Herein, we review other cases of primary intracranial NET, clinical findings, histopathological features and prognosis.

摘要

头皮偶然出现的软组织肿块是临床实践中常见的主诉。然而,它们可能预示着更严重的潜在病理情况。我们的报告检查了一名 63 岁男性,他在 3 个月的无痛左耳后头皮肿块病史后,左手协调性受损。MRI 显示左侧枕部大的软组织肿块穿透颅骨,向小脑和颞叶浸润。开放性活检证实为高级别颅内神经内分泌肿瘤(NET)。在成功切除肿瘤和辅助化疗后约 5 个月,他出现肿瘤复发,随后进行姑息治疗,诊断后 1 年死亡。在此,我们回顾了其他原发性颅内 NET、临床表现、组织病理学特征和预后的病例。

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本文引用的文献

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The 2019 WHO classification of tumours of the digestive system.2019年世界卫生组织消化系统肿瘤分类。
Histopathology. 2020 Jan;76(2):182-188. doi: 10.1111/his.13975. Epub 2019 Nov 13.
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Neuroendocrine tumors, version 1.2015.神经内分泌肿瘤,第 1.2015 版。
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Primary neuroendocrine tumor in brain.原发性脑内神经内分泌肿瘤
Case Rep Neurol Med. 2014;2014:295253. doi: 10.1155/2014/295253. Epub 2014 Nov 20.

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