Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan Province, China.
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Sci Rep. 2021 Feb 22;11(1):4304. doi: 10.1038/s41598-021-83654-7.
To determine the correlation between the clinical, laboratory, and radiological findings and the hospitalization days in Coronavirus Infectious Disease-19 (COVID-19) discharged patients. We retrospectively identified 172 discharged patients with COVID-19 pneumonia from January 10, 2020, to February 28, 2020, in Hunan province. The patients were categorized into group 1 (≤ 19 days) and group 2 (> 19 days) based on the time from symptom onset to discharge. Cough during admission occurred more commonly in group 2 (68.4%) than in group 1 (53.1%, p = 0.042). White blood cell (p = 0.045), neutrophil counts (p = 0.023), Alanine aminotransferase (p = 0.029), Aspartate aminotransferase (p = 0.027) and Lactate dehydrogenase (p = 0.021) that were above normal were more common in group 2. Patients with single lesions were observed more in group 1(17.7%, p = 0.018) and multiple lesions observed more in group 2(86.8%, p = 0.012). The number of lobes involved (p = 0.008) in the CT score (p = 0.001) for each patient was all differences between the two groups with a statistically significant difference. Mixed ground-glass opacity (GGO) and consolidation appearances were observed in most patients. GGO components > consolidation appearance was more common in group 1 (25.0%) than in group 2 (8.0%) with a significant difference (0.015), GGO < consolidation was more common in group 2(71.1%, p = 0.012). From the logistic regression analysis, the CT score (OR, 1.223; 95% CI, 1.004 to 1.491, p = 0.046) and the appearance of GGO > consolidation (OR, 0.150; 95% CI, 0.034 to 0.660, p = 0.012) were independently associated with the hospitalization days. Thus, special attention should be paid to the role of radiological features in monitoring the disease prognosis.
为了确定临床、实验室和影像学表现与新冠肺炎（COVID-19）出院患者住院天数之间的相关性。我们回顾性地确定了 2020 年 1 月 10 日至 2020 年 2 月 28 日期间在湖南省的 172 例新冠肺炎肺炎出院患者。根据从症状出现到出院的时间，患者被分为第 1 组（≤19 天）和第 2 组（>19 天）。第 2 组（68.4%）比第 1 组（53.1%）在入院时更常出现咳嗽（p=0.042）。白细胞计数（p=0.045）、中性粒细胞计数（p=0.023）、丙氨酸氨基转移酶（p=0.029）、天门冬氨酸氨基转移酶（p=0.027）和乳酸脱氢酶（p=0.021）升高更为常见。第 2 组中更常观察到单病灶（86.8%），而第 1 组中更常观察到多病灶（17.7%）（p=0.018）。在 CT 评分（p=0.001）中，每个患者的受累肺叶数（p=0.008）在两组之间均存在差异，差异具有统计学意义。大多数患者的混合磨玻璃密度影（GGO）和实变影表现。GGO 成分>实变影在第 1 组中更为常见（25.0%），而在第 2 组中则更为常见（8.0%），差异具有统计学意义（0.015），GGO<实变影在第 2 组中更为常见（71.1%），差异具有统计学意义（p=0.012）。通过逻辑回归分析，CT 评分（OR，1.223；95%CI，1.004 至 1.491，p=0.046）和 GGO>实变影的表现（OR，0.150；95%CI，0.034 至 0.660，p=0.012）与住院天数独立相关。因此，应特别注意影像学特征在监测疾病预后中的作用。
