Justice J B, Nicolaysen L C, Michael A C
Department of Chemistry, Emory University, Atlanta, GA 30322.
J Neurosci Methods. 1988 Jan;22(3):239-52. doi: 10.1016/0165-0270(88)90045-3.
A method is described for developing and evaluating models of neurochemical processes. Computer simulation and simplex optimization are used to examine a model of the dopaminergic nerve terminal of the rat striatum. In the model, synthesis, storage, release, uptake, and metabolism are described by a set of non-linear differential equations. Parameters of the model are optimized with respect to diverse experimental data. These data include steady state passage of radioactivity, decline in total dopamine after synthesis inhibition, and change in extracellular dopamine concentration during electrical stimulation.
本文描述了一种开发和评估神经化学过程模型的方法。利用计算机模拟和单纯形优化来研究大鼠纹状体多巴胺能神经末梢模型。在该模型中，合成、储存、释放、摄取和代谢由一组非线性微分方程描述。针对各种实验数据对模型参数进行优化。这些数据包括放射性的稳态通过、合成抑制后总多巴胺的下降以及电刺激期间细胞外多巴胺浓度的变化。
