Nicolaysen L C, Ikeda M, Justice J B, Neill D B
Department of Chemistry, Emory University, Atlanta, GA 30322.
Brain Res. 1988 Sep 13;460(1):50-9. doi: 10.1016/0006-8993(88)90428-3.
Released dopamine was monitored voltammetrically in the rat striatum in response to electrical stimulation of the nigrostriatal bundle. Stimulation parameters encompassed those typically used in behavioral studies. Dopamine released during intracranial self-stimulation (ICSS)-like stimulation reached a maximum within the first minute of stimulation, then rapidly decreased. The pattern of release obtained with continuous stimulation as a function of current and frequency supports the view that as the stimulation current is increased, a greater number of neurons are stimulated, while increasing the frequency of stimulation results in a fixed population of neurons being stimulated more intensely. Computer modeling of stimulated release from a population of dopaminergic nerve terminals was used to interpret effects of current and frequency and to predict ICSS release patterns as a function of schedule of reinforcement.
通过伏安法监测大鼠纹状体中因黑质纹状体束电刺激而释放的多巴胺。刺激参数包括行为研究中通常使用的参数。在类似颅内自我刺激（ICSS）的刺激过程中释放的多巴胺在刺激的第一分钟内达到最大值，然后迅速下降。连续刺激时多巴胺释放模式作为电流和频率的函数，支持以下观点：随着刺激电流增加，更多神经元受到刺激，而增加刺激频率会导致固定数量的神经元受到更强烈刺激。利用多巴胺能神经末梢群体刺激释放的计算机模型来解释电流和频率的影响，并预测作为强化程序函数的ICSS释放模式。
