Young S D, Michael A C
Department of Chemistry, Chevron Science Center, University of Pittsburgh, PA 15260.
Brain Res. 1993 Jan 15;600(2):305-7. doi: 10.1016/0006-8993(93)91387-8.
Fast-scan cyclic voltammetry in the striatum of anesthetized rats has been used to monitor extracellular dopamine during forced electrical stimulation of the media forebrain bundle using parameters that mimic intracranial self-stimulation. The temporal resolution provided by microelectrodes positioned very near sites of dopamine release allows resolution of the response to individual 500-ms stimulation trains separated by 500-ms intervals. Uptake inhibition by Nomifensine alters the resolution obtained at short times after initiation of stimulation.
在麻醉大鼠的纹状体中，快速扫描循环伏安法已被用于在模拟颅内自我刺激的参数下，对中脑前脑束进行强制电刺激期间监测细胞外多巴胺。位于非常接近多巴胺释放位点的微电极所提供的时间分辨率，能够分辨对以500毫秒间隔分开的单个500毫秒刺激序列的反应。诺米芬辛的摄取抑制作用会改变刺激开始后短时间内获得的分辨率。
