COVID-19 死亡率是生物年龄的指纹。
COVID-19 mortality as a fingerprint of biological age.
机构信息
Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Institute of Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
出版信息
Ageing Res Rev. 2021 May;67:101308. doi: 10.1016/j.arr.2021.101308. Epub 2021 Feb 20.
Corona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it becomes evident that the disease targets pathways and domains affected by the main aging- and frailty-related pathophysiological changes. A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognosis of COVID-19. There is a need for systematic, consequent action of identifying frail (not only older, not only multimorbid, not only symptomatic) persons at risk of poor outcomes.
2019 年冠状病毒病（COVID-19）是一场全球性紧急事件，能够使全球医疗保健能力不堪重负，并特别影响老年人群体。在探讨 COVID-19 的病理生理机制和临床表现时，显然该疾病针对的是受主要与衰老和虚弱相关的病理生理变化影响的途径和领域。对现有数据的更仔细分析支持了生物年龄而不是实际年龄在 COVID-19 预后中的可能作用。需要系统地采取一致行动，识别有发生不良结局风险的虚弱（不仅是老年人，不仅是多病，不仅是有症状）人群。
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