Badiye Ashish, Kapoor Neeti, Kumawat R K, Dixit Shivani, Mishra Aditi, Dixit Akansha, Kathane Prachi, Bag Sudeshna, Thakre Vaishnavi, Kaitholia Kamlesh, Srivastava Ankit, Chaubey Gyaneshwer, Shrivastava Pankaj
Department of Forensic Science, Government Institute of Forensic Science, Nagpur, Maharashtra, India.
DNA Division, State Forensic Science Laboratory, Jaipur, Rajasthan, India.
BMC Res Notes. 2021 Feb 23;14(1):69. doi: 10.1186/s13104-021-05485-z.
This study was planned to evaluate the genetic diversity in the admixed and Teli (a Hindu caste) populations of Maharashtra, India using 20 autosomal Short Tandem Repeat (STR) genetic markers. We further investigated the genetic relatedness of the studied populations with other Indian populations.
The studied populations showed a wide range of observed heterozygosity viz. 0.690 to 0.918 for the admixed population and 0.696 to 0.942 for the Teli population. This might be due to the multi-directional gene flow. The admixed and Teli populations also showed a high degree polymorphism which ranged from 0.652 to 0.903 and 0.644 to 0.902, respectively. Their combined value of matching probability for all the studied loci was 4.29 × 10 and 5.01 × 10, respectively. The results of Neighbor-Joining tree and Principal Component Analysis showed that the studied populations clustered with the general populations of Jharkhand, UttarPradesh, Rajasthan and Central Indian States, as well as with the specific populations of Maharashtra (Konkanastha Brahmins) and Tamil Nadu (Kurmans). Overall, the obtained data showed a high degree of forensic efficacy and would be useful for forensic applications as well as genealogical studies.
本研究旨在利用20个常染色体短串联重复序列（STR）基因标记评估印度马哈拉施特拉邦混合人群和泰利人群（印度一个印度教种姓）的遗传多样性。我们进一步研究了所研究人群与其他印度人群的遗传相关性。
所研究人群显示出广泛的观察杂合度，即混合人群为0.690至0.918，泰利人群为0.696至0.942。这可能是由于多方向的基因流动。混合人群和泰利人群也表现出高度多态性，范围分别为0.652至0.903和0.644至0.902。所有研究位点的匹配概率合并值分别为4.29×10和5.01×10。邻接树和主成分分析结果表明，所研究人群与贾坎德邦、北方邦、拉贾斯坦邦和印度中部各邦的一般人群，以及马哈拉施特拉邦（科纳斯塔婆罗门）和泰米尔纳德邦（库尔曼人）的特定人群聚类在一起。总体而言，所获得的数据显示出高度的法医效能，将对法医应用以及谱系研究有用。
