几丁质酶3样蛋白1基因分型与台湾地区哮喘风险的显著关联。
Significant Association of Chitinase 3-like 1 Genotypes to Asthma Risk in Taiwan.
作者信息
Chen Guan-Liang, Wang Shou-Cheng, Shen Te-Chun, Chang Wen-Shin, Lin Chingju, Hsia Te-Chun, Bau DA-Tian, Tsai Chia-Wen
机构信息
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Division of Chest Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
出版信息
In Vivo. 2021 Mar-Apr;35(2):799-803. doi: 10.21873/invivo.12320.
BACKGROUND/AIM: Chitinase 3-like 1 (CHI3L1) is overexpressed in asthma, and negatively associated with forced expiratory volume in the first second. This study aimed at evaluating whether CHI3L1 genotypes affect asthma risk.
MATERIALS AND METHODS
The blood samples of 198 asthma patients and 453 control subjects were collected, and the genotypic patterns of CHI3L1 -131C/G (rs4950928) and -247G/A (rs1262491437) were examined.
RESULTS
The percentages of CG and GG at CHI3L1 -131C/G were 32.8% and 7.6% among the asthma cases, respectively, significantly higher than the 23.8% and 3.1% among the non-asthmatic healthy subjects (p for trend=0.0009). The allelic frequency distribution analysis showed that the G allele at CHI3L1 - 131C/G conferred a significantly higher asthma risk than the wild-type C allele (p<0.0001). The genotypic and allelic frequency analyses for CHI3L1 -247G/A did not show any significant difference.
CONCLUSION
The G allele at CHI3L1-131C/G serves as a biomarker in determining personal susceptibility to asthma in Taiwan.
背景/目的：几丁质酶3样1（CHI3L1）在哮喘中表达上调，且与第一秒用力呼气量呈负相关。本研究旨在评估CHI3L1基因分型是否影响哮喘风险。
材料与方法
收集198例哮喘患者和453例对照者的血样，检测CHI3L1 -131C/G（rs4950928）和 -247G/A（rs1262491437）的基因分型模式。
结果
哮喘患者中CHI3L1 -131C/G位点CG和GG的比例分别为32.8%和7.6%，显著高于非哮喘健康受试者中的23.8%和3.1%（趋势p值 = 0.0009）。等位基因频率分布分析显示，CHI3L1 - 131C/G位点的G等位基因比野生型C等位基因导致哮喘风险显著更高（p<0.0001）。CHI3L1 -247G/A的基因分型和等位基因频率分析未显示任何显著差异。
结论
CHI3L1-131C/G位点的G等位基因可作为台湾地区哮喘个体易感性的生物标志物。
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