Alotaibi Moonef, Valova Valeria, HÄnsel Toni, Stromberger Carmen, Kofla Grzegorz, Olze Heidi, Piwonski Iris, Albers Andreas, Ochsenreither Sebastian, Coordes Annekatrin
Department of Otorhinolaryngology, Head and Neck Surgery (CVK and CCM), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
King Fahad Medical City, Department of Otorhinolaryngology, Head and Neck Surgery, Riyadh, Kingdom of Saudi Arabia.
In Vivo. 2021 Mar-Apr;35(2):1017-1026. doi: 10.21873/invivo.12345.
BACKGROUND/AIM: High risk Human papillomavirus (hr-HPV) and smoking are independant risk factors for head and neck squamous cell carcinomas (HNSCC). While hr-HPV HNSCC has a better prognosis than smoking-associated HNSCC no systematic data are yet available about the combined risk.
We performed a meta-analysis to assess the overall survival of HNSCC patients relative to the hr-HPV and smoking status. A literature review up to November 2019 was conducted in PubMed and Cochrane Library using the search terms 'HPV, Smoking and HNSCC'.
Nine out of 748 articles were included, 1,436 out of 2,080 patients were hr-HPV The prevalence of hr-HPV smokers was 36%. The meta-analysis showed a significantly better 5-year overall survival for HPV non-smokers compared to smokers with risk ratio of 1.94 (95% confidence intervaI=1.46-2.58).
Smoking is a negative prognostic factor for overall survival in patients with hr-HPV HNSCC and should thus be an important part of staging and treatment.
背景/目的：高危型人乳头瘤病毒（hr-HPV）和吸烟是头颈部鳞状细胞癌（HNSCC）的独立危险因素。虽然hr-HPV相关的HNSCC比吸烟相关的HNSCC预后更好，但关于联合风险尚无系统数据。
我们进行了一项荟萃分析，以评估HNSCC患者相对于hr-HPV和吸烟状态的总生存期。截至2019年11月，在PubMed和Cochrane图书馆进行了文献综述，使用检索词“HPV、吸烟与HNSCC”。
748篇文章中有9篇被纳入，2080例患者中有1436例为hr-HPV。hr-HPV吸烟者的患病率为36%。荟萃分析显示，与吸烟者相比，HPV非吸烟者的5年总生存期显著更好，风险比为1.94（95%置信区间=1.46-2.58）。
吸烟是hr-HPV相关HNSCC患者总生存期的不良预后因素，因此应成为分期和治疗的重要组成部分。
