Zhu Jing, Zhou Rui, Wang Yihan, Yu Min
Department of Oncology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Acta Otolaryngol. 2019 Nov;139(11):1038-1043. doi: 10.1080/00016489.2019.1655167. Epub 2019 Aug 29.
Squamous cell carcinoma (SCC) is the most common type of head and neck cancer, and head and neck squamous cell carcinoma (HNSCC) was proved to having a high prevalence of perineural invasion (PNI). Although some reports have revealed a relationship between PNI and the prognosis in HNSCC patients, the contribution of PNI to the prognosis remains unclear. This study was aimed to comprehensively and quantitatively summarize the prognostic value of PNI for the survival of patients with HNSCC. We conducted PubMed and EMBASE to identify all relevant studies. A meta-analysis and subgroup analysis were performed to clarify the prognostic role of PNI. A total of 18 studies ( = 3894) were included. 989 (25.4%) of the 3894 patients exhibited positive PNI, PNI was shown to be significantly associated with overall survival (OS) [hazard ratio (HR): 2.8, 95% confidence interval (CI): 1.88-4.16], disease-free survival (DFS) (HR = 2.42, 95% CI: 1.92-3.05) and disease-specific survival (DSS) (HR = 2.60, 95% CI: 1.86-3.63). The presence of PNI significantly affected OS, DFS and DSS in patients with HNSCC.
鳞状细胞癌（SCC）是头颈部最常见的癌症类型，头颈部鳞状细胞癌（HNSCC）被证实具有较高的神经周围侵犯（PNI）发生率。尽管一些报告揭示了PNI与HNSCC患者预后之间的关系，但PNI对预后的影响仍不明确。本研究旨在全面、定量地总结PNI对HNSCC患者生存的预后价值。我们在PubMed和EMBASE上检索以确定所有相关研究。进行荟萃分析和亚组分析以阐明PNI的预后作用。共纳入18项研究（n = 3894）。3894例患者中有989例（25.4%）PNI呈阳性，PNI与总生存期（OS）[风险比（HR）：2.8，95%置信区间（CI）：1.88 - 4.16]、无病生存期（DFS）（HR = 2.42，95% CI：1.92 - 3.05）和疾病特异性生存期（DSS）（HR = 2.60，95% CI：1.86 - 3.63）显著相关。PNI的存在显著影响HNSCC患者的OS、DFS和DSS。
