Division for Regional Cancer Control, Gifu University Graduate School of Medicine, Gifu, Japan.
Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan.
Sci Rep. 2021 Feb 23;11(1):4348. doi: 10.1038/s41598-021-83007-4.
Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms. This retrospective study enrolled a total of 758 patients who underwent both FIT and total colonoscopy. The effect of antithrombotic drugs on FIT accuracy in detecting colorectal neoplasms (CN), including colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA), was examined. Of the 758 patients, 144 (19%) received antithrombotic drugs (administration group). In administration group, 61/144 (42%) cases had CN [CRC:14, AA:15, NAA:32] and 217/614 (35%) cases had CN (CRC:43, AA:56, NAA:118) in non-administration group. The prevalence of CN was not significantly different between the two groups (p = 0.1157). There was no significant difference in sensitivity or specificity of the detection of all types of CN with or without taking antithrombotic drugs. Neither the positive predictive value nor negative predictive value of FIT was affected by antithrombotic drug administration. Taking antithrombotic drugs may not have a large impact on sensitivity, specificity, positive predictive value, or negative predictive value of FIT in screening for CN.
粪便免疫化学检测（FIT）被广泛用作结直肠癌筛查工具。抗血栓药物可能会影响 FIT 对结直肠肿瘤的筛查性能。本研究旨在阐明抗血栓药物对 FIT 检测结直肠肿瘤（CN），包括结直肠癌（CRC）、高级别腺瘤（AA）和非高级别腺瘤（NAA）准确性的影响。本回顾性研究共纳入了 758 名同时接受 FIT 和全结肠镜检查的患者。研究考察了抗血栓药物对 FIT 检测结直肠肿瘤（CN），包括结直肠癌（CRC）、高级别腺瘤（AA）和非高级别腺瘤（NAA）准确性的影响。在 758 名患者中，144 名（19%）患者接受了抗血栓药物治疗（用药组）。在用药组中，61 例（42%）患者存在 CN[CRC：14 例，AA：15 例，NAA：32 例]，而在非用药组中，217 例（35%）患者存在 CN[CRC：43 例，AA：56 例，NAA：118 例]。两组患者的 CN 患病率无显著差异（p=0.1157）。服用或未服用抗血栓药物对所有类型 CN 的检测敏感性或特异性均无显著差异。FIT 的阳性预测值或阴性预测值也不受抗血栓药物使用的影响。服用抗血栓药物对 FIT 筛查 CN 的敏感性、特异性、阳性预测值或阴性预测值可能影响不大。
