Armario A, Hidalgo J, Giralt M
Departamento de Biología Celular y Fisiología, Facultad de Ciencas, Universidad Autónoma Barcelona, Bellaterra, Spain.
Neuroendocrinology. 1988 Mar;47(3):263-7. doi: 10.1159/000124921.
The effects of previous chronic immobilization stress on the physiological responses of male rats to a novel chronic stressor (shock) were studied. Previous chronic exposure to immobilization reduced adrenocorticotropin (ACTH) and lactate responses to acute immobilization stress without altering the response to a novel acute stressor (tail shock). When subjected to chronic tail shock, body weight inhibition caused by chronic shock was greater in the rats not previously exposed to chronic immobilization, which suggests that there is cross-adaptation between different stressors. However, adrenocorticotropin adaptation to chronic shock was impaired by previous chronic immobilization. These data indicate that the existence of cross-adaptation to stressors might depend on the variable measured, the central nervous system pathways controlling the pituitary-adrenal axis being, apparently, resistant to cross-adaptation. This lack of cross-adaptation at certain levels can assure the maintenance of an adequate response to unknown environmental stimuli.
研究了先前慢性束缚应激对雄性大鼠面对新的慢性应激源（电击）时生理反应的影响。先前长期暴露于束缚状态下，会降低促肾上腺皮质激素（ACTH）和乳酸对急性束缚应激的反应，而不会改变对新的急性应激源（尾部电击）的反应。当遭受慢性尾部电击时，先前未暴露于慢性束缚的大鼠，由慢性电击引起的体重抑制作用更大，这表明不同应激源之间存在交叉适应。然而，先前的慢性束缚会损害促肾上腺皮质激素对慢性电击的适应性。这些数据表明，对应激源的交叉适应的存在可能取决于所测量的变量，显然，控制垂体-肾上腺轴的中枢神经系统途径对交叉适应具有抗性。在某些水平上缺乏这种交叉适应可以确保对未知环境刺激保持适当的反应。
