Garcia-Marquez C, Armario A
Physiol Behav. 1987;40(1):33-8. doi: 10.1016/0031-9384(87)90182-x.
The present study investigated the effects of chronic stress on some behavioral and endocrine variables in adult male rats. The variables were always measured the day that followed the stress session to chronically stressed rats. Two stress models were used: chronic shock (CS), and a combination of various stressors randomly chosen each day (CV). Chronic but not acute exposure to the stressors resulted in decreased exploratory activity in the holeboard. Likewise, only chronic exposure to shock or variable stressors resulted in increased immobility in the Porsolt's test. Taken together these results suggest that changes in exploratory and forced swimming activities might be affected by chronic stress. In contrast, neither CS nor CV rats showed altered basal or stress-induced levels of ACTH which suggests that the activity of the axis was unchanged. Although the present data indicate that chronic stress caused behavioral abnormalities closely related to that expected to take place in some type of depressive disorders, endocrine data are not in good agreement with those occurring in depression.
本研究调查了慢性应激对成年雄性大鼠某些行为和内分泌变量的影响。这些变量总是在对慢性应激大鼠进行应激实验后的第二天进行测量。使用了两种应激模型：慢性电击（CS），以及每天随机选择的各种应激源的组合（CV）。长期而非急性暴露于应激源会导致在洞板实验中探索活动减少。同样，只有长期暴露于电击或可变应激源会导致在波索尔特实验中不动时间增加。综合这些结果表明，探索和强迫游泳活动的变化可能受慢性应激影响。相比之下，CS组和CV组大鼠的促肾上腺皮质激素基础水平或应激诱导水平均未改变，这表明该轴的活性未变。尽管目前的数据表明慢性应激导致了与某些类型抑郁症预期发生情况密切相关的行为异常，但内分泌数据与抑郁症中的情况并不完全一致。
