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生长抑素受体分子成像在一例胃泌素瘤误诊病例中的应用

Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case.

作者信息

Stolniceanu Cati Raluca, Grierosu Irena Cristina, Matovic Milovan, Stefanescu Cipriana

机构信息

Department of Biophysics and Medical Physics, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Nuclear Medicine Laboratory, "ST. Spiridon" Emergency County Hospital, Iasi, Romania.

出版信息

World J Nucl Med. 2020 Aug 22;19(4):417-420. doi: 10.4103/wjnm.WJNM_16_20. eCollection 2020 Oct-Dec.

DOI:10.4103/wjnm.WJNM_16_20
PMID:33623513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7875036/
Abstract

Gastrin-secreting tumors, hypergastrinemia and severe ulcer disease form the trademarks of Zollinger-Ellison syndrome (ZES). We report a case of gastrinoma, in a patient who was misdiagnosed for almost five years. The case emphsizes the the special role of functional imaging in the personalized approach to the patient with suggestive symptomatology for NETs. Taking into account that in 80 to 100% of cases of gastroenteropancreatic (GEP) NETs are expressing somatostatin receptors, the functional imaging with radiolabeled somatostatin analogues can be used in order to improve its diagnosis, respectively the treatment of GEP NETs. In the approach to the patient with tremendous digestive symptomatology, physicians from different specialties should evaluate NETs specific markers and then insist on structural-functional complementarity, avoiding the waste of time and high cost of repeated structural investigations. The conclusion of our study is that functional imaging is mandatory in the diagnostic algorithm of gastrinoma.

摘要

胃泌素分泌肿瘤、高胃泌素血症和严重溃疡病构成了卓-艾综合征（ZES）的特征。我们报告了一例胃泌素瘤病例，该患者被误诊了近五年。该病例强调了功能成像在对具有神经内分泌肿瘤（NETs）提示性症状的患者进行个性化治疗中的特殊作用。考虑到80%至100%的胃肠胰（GEP）NETs病例表达生长抑素受体，使用放射性标记的生长抑素类似物进行功能成像可用于改善GEP NETs的诊断及治疗。在面对有严重消化症状的患者时，不同专业的医生应评估NETs的特异性标志物，然后坚持结构-功能互补性，避免重复进行结构检查浪费时间和产生高昂费用。我们研究的结论是，功能成像在胃泌素瘤的诊断算法中是必不可少的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92af/7875036/b93190e38308/WJNM-19-417-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92af/7875036/2a90852342f7/WJNM-19-417-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92af/7875036/0de7c7eeb208/WJNM-19-417-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92af/7875036/b93190e38308/WJNM-19-417-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92af/7875036/2a90852342f7/WJNM-19-417-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92af/7875036/0de7c7eeb208/WJNM-19-417-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92af/7875036/b93190e38308/WJNM-19-417-g003.jpg

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World J Nucl Med. 2019 Apr-Jun;18(2):137-142. doi: 10.4103/wjnm.WJNM_36_18.
2
Somatostatin receptor PET ligands - the next generation for clinical practice.生长抑素受体PET配体——临床应用的新一代产品
Am J Nucl Med Mol Imaging. 2018 Oct 20;8(5):311-331. eCollection 2018.
3
Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing.
在质子泵抑制剂时代、胃泌素检测存在缺陷、影像检查敏感且胃酸分泌检测受限的情况下对卓-艾综合征的诊断
Int J Endocr Oncol. 2017;4(4):167-185. doi: 10.2217/ije-2017-0018. Epub 2017 Oct 11.
4
The Zollinger-Ellison syndrome: is there a role for somatostatin analogues in the treatment of the gastrinoma?佐林格-埃利森综合征：生长抑素类似物在治疗胃泌素瘤中有作用吗？
Endocrine. 2018 Apr;60(1):15-27. doi: 10.1007/s12020-017-1420-4. Epub 2017 Oct 10.
5
Catching the Zebra: Clinical Pearls and Pitfalls for the Successful Diagnosis of Zollinger-Ellison Syndrome.捕捉“斑马”：卓-艾综合征成功诊断的临床要点与陷阱
Dig Dis Sci. 2017 Sep;62(9):2258-2265. doi: 10.1007/s10620-017-4695-7. Epub 2017 Aug 3.
6
Imaging of neuroendocrine tumors of the pancreas.胰腺神经内分泌肿瘤的影像学表现。
Diagn Interv Imaging. 2016 Dec;97(12):1241-1257. doi: 10.1016/j.diii.2016.07.012. Epub 2016 Nov 18.
7
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Arch Med Sci. 2016 Feb 1;12(1):1-9. doi: 10.5114/aoms.2016.57577. Epub 2016 Feb 2.
9
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Best Pract Res Clin Gastroenterol. 2012 Dec;26(6):719-35. doi: 10.1016/j.bpg.2013.01.002.