Al Bulushi Naima, Al Suqri Badriya, Al Aamri Marwa, Al Hadidi Aymen, Al Jahdami Hafidh, Al Zadjali Mohammed, Al Risi Mimouna
Department of Nuclear Medicine and Molecular Imaging Center, Royal Hospital, Muscat, Oman.
Department of Radiology, Al Nahda Hospital, Muscat, Oman.
World J Nucl Med. 2019 Apr-Jun;18(2):137-142. doi: 10.4103/wjnm.WJNM_36_18.
The aim of this observational cross-sectional study with retrospective review of the data is to evaluate the efficacy of using technetium-99m-octreotide (Tc-99m-OCT) in imaging neuroendocrine tumors (NETs) in our tertiary care hospital. A total of 58 patients had Tc-99m-OCT were identified in our database, from January 2013 to December 2016. Forty-one patients (age range of 15-75 years) meet our inclusion criteria, namely histopathology proven NETs, Tc-99m-OCT scan, computed tomography (CT), or magnetic resonance imaging (MRI) done in our institute for correlation. Twenty-three patients had true positive Tc-99m-OCT scan. In addition to the primary tumors, the octreotide scan revealed metastasis in the lung, liver, and retroperitoneal lymph nodes. The smallest lesion detected on octreotide scan was a 4-mm pulmonary nodule that was missed on lung window CT scan. The Tc-99m-OCT had 17 true negative, one false negative, and no false positive. The CT and MRI scans had 18 true positive, 17 true negative, 5 false negative, and one false positive. The overall sensitivity, specificity, accuracy, positive, and negative predictive values of Tc-99m-OCT scan were 96%, 100%, 97%, 100%, and 94%, respectively. Whereas those of CT and MRI were 78%, 94%, 85%, 94%, and 77%, respectively. Our diagnostic accuracy of Tc-99m-OCT is high. We recommend that, in addition to the conventional radiological investigations, Tc-99m-OCT scan, or other somatostatin receptor imaging (SSR) is a mandate for better and accurate staging of patients with NETs.
这项带有数据回顾性分析的观察性横断面研究旨在评估在我们的三级护理医院中使用锝-99m-奥曲肽（Tc-99m-OCT）对神经内分泌肿瘤（NETs）进行成像的疗效。在我们的数据库中，共识别出58例接受过Tc-99m-OCT检查的患者，时间跨度为2013年1月至2016年12月。41例患者（年龄范围为15至75岁）符合我们的纳入标准，即经组织病理学证实为NETs，且在我们研究所进行了Tc-99m-OCT扫描、计算机断层扫描（CT）或磁共振成像（MRI）以作对照。23例患者的Tc-99m-OCT扫描结果为真阳性。除了原发性肿瘤外，奥曲肽扫描还显示在肺、肝和腹膜后淋巴结有转移。奥曲肽扫描检测到的最小病变是一个4毫米的肺结节，在肺窗CT扫描中被漏诊。Tc-99m-OCT有17例假阴性、1例假阳性，无假阳性。CT和MRI扫描有18例假阳性、17例假阴性、5例假阴性和1例假阳性。Tc-99m-OCT扫描的总体敏感性、特异性、准确性、阳性预测值和阴性预测值分别为96%、100%、97%、100%和94%。而CT和MRI的相应数值分别为78%、94%、85%、94%和77%。我们的Tc-99m-OCT诊断准确性很高。我们建议，除了传统的放射学检查外，Tc-99m-OCT扫描或其他生长抑素受体成像（SSR）对于更好、更准确地对NETs患者进行分期是必要的。
