线粒体脑肌病伴乳酸血症和卒中样发作综合征：典型的偏头痛和癫痫特征以及母系遗传。

MELAS syndrome: characteristic migrainous and epileptic features and maternal transmission.

作者信息

Montagna P, Gallassi R, Medori R, Govoni E, Zeviani M, Di Mauro S, Lugaresi E, Andermann F

机构信息

Institute of Neurology, University of Bologna, Italy.

出版信息

Neurology. 1988 May;38(5):751-4. doi: 10.1212/wnl.38.5.751.

DOI:10.1212/wnl.38.5.751

PMID:3362373

Abstract

Severe prolonged migrainous symptoms and prolonged partial status epilepticus are characteristic features of the MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). Maternal transmission previously found in myoclonus epilepsy and ragged-red fibers (MERRF), another mitochondrial disease, is suggested in this disorder as well.

摘要

严重的长期偏头痛症状和长期部分性癫痫持续状态是线粒体脑肌病伴乳酸酸中毒及卒中样发作（MELAS综合征）的特征性表现。此前在另一种线粒体疾病——肌阵挛性癫痫伴破碎红纤维（MERRF）中发现的母系遗传，在该疾病中也有提示。