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作为新冠疫情封锁解除策略一部分的社交气泡的有效性:一项建模研究

The effectiveness of social bubbles as part of a Covid-19 lockdown exit strategy, a modelling study.

作者信息

Leng Trystan, White Connor, Hilton Joe, Kucharski Adam, Pellis Lorenzo, Stage Helena, Davies Nicholas G, Keeling Matt J, Flasche Stefan

机构信息

The Zeeman Institute for Systems Biology & Infectious Disease Epidemiology Research, University of Warwick, Coventry, UK.

Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.

出版信息

Wellcome Open Res. 2021 Mar 29;5:213. doi: 10.12688/wellcomeopenres.16164.2. eCollection 2020.

Abstract

During the coronavirus disease 2019 (COVID-19) lockdown, contact clustering in social bubbles may allow extending contacts beyond the household at minimal additional risk and hence has been considered as part of modified lockdown policy or a gradual lockdown exit strategy. We estimated the impact of such strategies on epidemic and mortality risk using the UK as a case study. We used an individual based model for a synthetic population similar to the UK, stratified into transmission risks from the community, within the household and from other households in the same social bubble. The base case considers a situation where non-essential shops and schools are closed, the secondary household attack rate is 20% and the initial reproduction number is 0.8. We simulate social bubble strategies (where two households form an exclusive pair) for households including children, for single occupancy households, and for all households. We test the sensitivity of results to a range of alternative model assumptions and parameters.   Clustering contacts outside the household into exclusive bubbles is an effective strategy of increasing contacts while limiting the associated increase in epidemic risk. In the base case, social bubbles reduced fatalities by 42% compared to an unclustered increase of contacts. We find that if all households were to form social bubbles the reproduction number would likely increase to above the epidemic threshold of R=1. Strategies allowing households with young children or single occupancy households to form social bubbles increased the reproduction number by less than 11%. The corresponding increase in mortality is proportional to the increase in the epidemic risk but is focussed in older adults irrespective of inclusion in social bubbles. If managed appropriately, social bubbles can be an effective way of extending contacts beyond the household while limiting the increase in epidemic risk.

摘要

在2019冠状病毒病(COVID-19)封锁期间,社交泡泡中的接触聚集可能会以最小的额外风险让接触范围扩大到家庭之外,因此被视为修改后的封锁政策或逐步解封策略的一部分。我们以英国为例,估计了此类策略对疫情和死亡风险的影响。我们使用了一个基于个体的模型来模拟一个与英国类似的合成人群,该人群按社区传播风险、家庭内部传播风险以及同一社交泡泡中其他家庭的传播风险进行分层。基准情形考虑非必要商店和学校关闭、家庭二代感染率为20%且初始繁殖数为0.8的情况。我们针对有孩子的家庭、单人居住家庭以及所有家庭模拟社交泡泡策略(两个家庭结成排他性对子)。我们测试了结果对一系列替代模型假设和参数的敏感性。将家庭之外的接触聚集到排他性泡泡中是一种在增加接触的同时限制相关疫情风险增加的有效策略。在基准情形下,与非聚集性接触增加相比,社交泡泡使死亡人数减少了42%。我们发现,如果所有家庭都结成社交泡泡,繁殖数可能会增加到高于疫情阈值R = 1。允许有幼儿的家庭或单人居住家庭结成社交泡泡的策略使繁殖数增加不到11%。相应的死亡人数增加与疫情风险增加成正比,但集中在老年人中,无论是否纳入社交泡泡。如果管理得当,社交泡泡可以成为一种在扩大家庭之外接触范围的同时限制疫情风险增加的有效方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cc2/8008352/bfdab1119531/wellcomeopenres-5-18467-g0000.jpg

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