Bejm Karolina, Wojtkiewicz Stanislaw, Pastuszak Zanna, Liebert Adam
Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
Laboratory of Preclinical Research and Environmental Agents, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Biomed Opt Express. 2025 Mar 17;16(4):1457-1470. doi: 10.1364/BOE.545722. eCollection 2025 Apr 1.
The influence of hypoxia - a condition where tissues are under oxygen deficiency - on the human brain under functional load has not been fully understood yet. This study aims to analyse the effects of hypoxia on the brain's haemodynamic response under visual stimulation, using the in-house developed functional near-infrared spectroscopy system and to quantify the hemodynamic response. Our results (median, 25 and 75 percentile) demonstrate the amplitude of the oxygenated haemoglobin functional response during hypoxia 0.30 µM (0.27, 0.41) was lower compared with the normoxia 0.63 µM (0.54, 0.93) and hyperoxia 0.73 µM (0.43, 1.09). No statistical significance is observed for the deoxygenated haemoglobin changes. The hypoxia has a statistically significant effect on the amplitude of the haemodynamic response (p < 0.001).
缺氧（即组织处于缺氧状态）对处于功能负荷下的人脑的影响尚未完全明确。本研究旨在使用内部开发的功能近红外光谱系统，分析缺氧对视觉刺激下大脑血液动力学反应的影响，并对血液动力学反应进行量化。我们的结果（中位数、第25和第75百分位数）表明，缺氧期间氧合血红蛋白功能反应的幅度为0.30 μM（0.27，0.41），低于常氧状态下的0.63 μM（0.54，0.93）和高氧状态下的0.73 μM（0.43，1.09）。脱氧血红蛋白变化未观察到统计学显著性。缺氧对血液动力学反应的幅度具有统计学显著影响（p < 0.001）。
