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Hematologic Rescue of CAR T-cell-mediated Prolonged Pancytopenia Using Autologous Peripheral Blood Hematopoietic Stem Cells in a Lymphoma Patient.

作者信息

Gödel Philipp, Sieg Noëlle, Heger Jan-Michel, Kutsch Nadine, Herling Carmen, Bärmann Ben-Niklas, Scheid Christof, Borchmann Peter, Holtick Udo

机构信息

Cologne Lymphoma Working Group, Department of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.

Center for Integrated Oncology Aachen Bonn Köln Düsseldorf (CIO ABCD), Germany.

出版信息

Hemasphere. 2021 Feb 17;5(3):e545. doi: 10.1097/HS9.0000000000000545. eCollection 2021 Mar.

DOI:10.1097/HS9.0000000000000545

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7892295/

Abstract

摘要

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[2]

Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion.

Sci Adv. 2023-9-22

[3]

Prolonged haematologic toxicity in CAR-T-cell therapy: A review.

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[4]

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[5]

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[6]

Safety and feasibility of stem cell boost as a salvage therapy for severe hematotoxicity after CD19 CAR T-cell therapy.

Blood Adv. 2022-8-23

[7]

CD34+-selected stem cell boost can safely improve cytopenias following CAR T-cell therapy.

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[8]

CAR-T Cells/-NK Cells in Cancer Immunotherapy and the Potential of MSC to Enhance Its Efficacy: A Review.

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[9]

Cytopenia after CAR-T Cell Therapy-A Brief Review of a Complex Problem.

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[10]

CAR-HEMATOTOX: a model for CAR T-cell-related hematologic toxicity in relapsed/refractory large B-cell lymphoma.

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本文引用的文献

[1]

Hematopoietic recovery in patients receiving chimeric antigen receptor T-cell therapy for hematologic malignancies.

Blood Adv. 2020-8-11

[2]

Hematopoietic recovery and immune reconstitution after axicabtagene ciloleucel in patients with large B-cell lymphoma.

Haematologica. 2021-10-1

[3]

Incidence and risk factors associated with a syndrome of persistent cytopenias after CAR-T cell therapy (PCTT).

Leuk Lymphoma. 2020-4

[4]

Autologous hematopoietic stem cell infusion for sustained myelosuppression after BCMA-CAR-T therapy in patient with relapsed myeloma.

Bone Marrow Transplant. 2020-6

[5]

Early and late hematologic toxicity following CD19 CAR-T cells.

Bone Marrow Transplant. 2019-10

[6]

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.

Lancet Oncol. 2018-12-2

[7]

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.

N Engl J Med. 2018-12-1

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