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Safety and feasibility of stem cell boost as a salvage therapy for severe hematotoxicity after CD19 CAR T-cell therapy.

作者信息

Rejeski Kai, Burchert Andreas, Iacoboni Gloria, Sesques Pierre, Fransecky Lars, Bücklein Veit, Trenker Corinna, Hernani Rafael, Naumann Ralph, Schäfer Jonas, Blumenberg Viktoria, Schmidt Christian, Sohlbach Kristina, von Bergwelt-Baildon Michael, Bachy Emmanuel, Barba Pere, Subklewe Marion

机构信息

Department of Medicine III, Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany.

Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany.

出版信息

Blood Adv. 2022 Aug 23;6(16):4719-4725. doi: 10.1182/bloodadvances.2022007776.

DOI:10.1182/bloodadvances.2022007776
PMID:35793454
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9631678/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bee/9631678/4a9d62dded87/advancesADV2022007776f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bee/9631678/129bcf464318/advancesADV2022007776absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bee/9631678/4a9d62dded87/advancesADV2022007776f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bee/9631678/129bcf464318/advancesADV2022007776absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bee/9631678/4a9d62dded87/advancesADV2022007776f1.jpg

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The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL.嵌合抗原受体 T 细胞(CAR-T)治疗后复发/难治性大 B 细胞淋巴瘤(R/R LBCL)患者的 CAR-HEMATOTOX 风险可预测严重感染和疾病进展。
J Immunother Cancer. 2022 May;10(5). doi: 10.1136/jitc-2021-004475.
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GLA/DRST real-world outcome analysis of CAR T-cell therapies for large B-cell lymphoma in Germany.德国 GLA/DRST 真实世界研究分析嵌合抗原受体 T 细胞疗法治疗大 B 细胞淋巴瘤的结果。
Blood. 2022 Jul 28;140(4):349-358. doi: 10.1182/blood.2021015209.
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The bone marrow niche components are adversely affected in sepsis.
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Fatal recurrence of IEC-HS after autologous stem cell boost in patients receiving BCMA-CAR T-cell therapy.接受BCMA嵌合抗原受体T细胞疗法的患者在自体干细胞强化治疗后发生侵袭性上皮内癌-高侵袭性亚型的致命复发。
Blood Adv. 2025 Aug 12;9(15):3832-3836. doi: 10.1182/bloodadvances.2025016346.
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