Department of Organic Chemistry, Faculty of Chemistry, Vilnius University, Naugarduko 24, Vilnius LT-03225, Lithuania.
Bioorg Med Chem Lett. 2010 Mar 1;20(5):1504-6. doi: 10.1016/j.bmcl.2010.01.112. Epub 2010 Jan 25.
A series of 2-substituted 1,2-dihydro-3-phenyl-1-(trichloromethyl)benzo[b][1,6]naphthyridines were synthesized and their in vitro antiproliferative activities were examined against human solid tumor cell lines and relevant strains of bacteria and Candida. The compounds induced considerably growth inhibition in all cancer cell lines, whilst showed inactive against microbial strains. Furthermore, we found analog 2-ethoxy-1H-pyrano[4,3-b]quinoline as selective inhibitor of microbial strains.
合成了一系列 2-取代的 1,2-二氢-3-苯基-1-(三氯甲基)苯并[b][1,6]萘啶，并对其进行了体外抗人类实体瘤细胞系和相关细菌及念珠菌的活性检测。这些化合物对所有癌细胞系都有显著的生长抑制作用，而对微生物株则无活性。此外，我们发现类似物 2-乙氧基-1H-吡喃并[4,3-b]喹啉是微生物株的选择性抑制剂。
